Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 8/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | G6PD | P11413 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | BID | P55957 | 3/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.37 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.37 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28904223 | 0.98 | LTB4R (0.44) | LTB4RGPR35ALDH1A1TP53HSP90AA1 | |
| SCHEMBL20228012 | 0.94 | LTB4R (0.41) | LTB4RGPR35ALDH1A1TP53HSP90AA1 | |
| SCHEMBL87684 | 0.90 | LTB4R (0.47) | LTB4RTP53CYP3A4ALOX15TSHR | |
| SCHEMBL28748437 | 0.88 | LTB4R (0.39) | LTB4RGPR35 | |
| SCHEMBL15648187 | 0.88 | LTB4R (0.49) | LTB4RGPR35TP53CYP3A4ALOX15 | |
| SCHEMBL14690810 | 0.88 | LTB4R (0.49) | LTB4RGPR35TP53CYP3A4ALOX15 | |
| SCHEMBL6260351 | 0.88 | LTB4R (0.49) | LTB4RGPR35TP53CYP3A4ALOX15 | |
| SCHEMBL15152496 | 0.88 | LTB4R (0.49) | LTB4RGPR35TP53CYP3A4ALOX15 | |
| SCHEMBL28854260 | 0.88 | LTB4R (0.49) | LTB4RGPR35TP53CYP3A4ALOX15 | |
| SCHEMBL3230612 | 0.88 | LTB4R (0.46) | LTB4RTP53CYP3A4ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507245-B1 | MULTICYCLIC COMPOUNDS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC (US) | 2017-04-12 | — | — | EP | disclosed |