Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 18/20 | 0.53 |
| ▸ | ACE | P12821 | 8/20 | 0.51 |
| ▸ | EMG1 | Q92979 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17011171 | 1.00 | MME (0.53) | MMEACEEMG1 | |
| SCHEMBL19190250 | 0.89 | MME (0.49) | MMEACEEMG1 | |
| SCHEMBL17011170 | 0.89 | MME (0.58) | MMEACEEMG1 | |
| SCHEMBL18724854 | 0.89 | MME (0.58) | MMEACEEMG1 | |
| SCHEMBL17011173 | 0.88 | MME (0.55) | MMEACEEMG1 | |
| SCHEMBL9930506 | 0.88 | MME (0.68) | MMEACEEMG1 | |
| SCHEMBL17011174 | 0.87 | MME (0.60) | MMEACEEMG1 | |
| SCHEMBL17011172 | 0.87 | MME (0.53) | MMEACEEMG1 | |
| SCHEMBL18724876 | 0.86 | MME (0.70) | MMEACE | |
| SCHEMBL9930536 | 0.86 | MME (0.70) | MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3199517-A1 | NEPRILYSIN INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2017-08-02 | — | — | EP | disclosed |
| EP-2864292-B1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2017-04-12 | — | — | EP | disclosed |