Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 20/20 | 0.70 |
| ▸ | ACE | P12821 | 5/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9930536 | 1.00 | MME (0.70) | MMEACE | |
| SCHEMBL17011170 | 0.91 | MME (0.58) | MMEACE | |
| SCHEMBL18724854 | 0.91 | MME (0.58) | MMEACE | |
| SCHEMBL17011174 | 0.90 | MME (0.60) | MMEACE | |
| SCHEMBL9930294 | 0.89 | MME (0.77) | MMEACE | |
| SCHEMBL9930506 | 0.89 | MME (0.68) | MMEACE | |
| SCHEMBL17011180 | 0.87 | ACE (0.59) | MMEACE | |
| SCHEMBL18724754 | 0.87 | ACE (0.59) | MMEACE | |
| SCHEMBL19708615 | 0.86 | MME (0.64) | MMEACE | |
| SCHEMBL18724848 | 0.86 | MME (0.53) | MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3199517-A1 | NEPRILYSIN INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2017-08-02 | — | — | EP | disclosed |
| EP-2864292-B1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2017-04-12 | — | — | EP | disclosed |