Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 18/20 | 0.63 |
| ▸ | ACE | P12821 | 7/20 | 0.63 |
| ▸ | MMEL1 | Q495T6 | 5/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17011373 | 1.00 | MME (0.63) | MMEACEMMEL1 | |
| SCHEMBL18724988 | 0.91 | MME (0.56) | MMEACEMMEL1 | |
| SCHEMBL17011374 | 0.91 | MME (0.56) | MMEACEMMEL1 | |
| SCHEMBL19190446 | 0.90 | MME (0.59) | MMEACEMMEL1 | |
| SCHEMBL17011366 | 0.90 | MME (0.59) | MMEACEMMEL1 | |
| SCHEMBL18597872 | 0.85 | MME (0.70) | MMEACEMMEL1 | |
| SCHEMBL14890711 | 0.85 | MME (0.70) | MMEACEMMEL1 | |
| SCHEMBL14902416 | 0.83 | MME (0.57) | MMEACEMMEL1 | |
| SCHEMBL19190318 | 0.83 | MME (0.57) | MMEACEMMEL1 | |
| SCHEMBL14900581 | 0.83 | MME (0.59) | MMEACEMMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2864292-B1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2017-04-12 | — | — | EP | disclosed |