Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 16/20 | 0.57 |
| ▸ | ACE | P12821 | 8/20 | 0.57 |
| ▸ | MMEL1 | Q495T6 | 5/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18724863 | 0.90 | MME (0.57) | MMEACEMMEL1ADRB1ADRB3 | |
| SCHEMBL17011196 | 0.90 | MME (0.57) | MMEACEMMEL1ADRB1ADRB3 | |
| SCHEMBL18724860 | 0.83 | MME (0.63) | MMEACEMMEL1 | |
| SCHEMBL17011373 | 0.83 | MME (0.63) | MMEACEMMEL1 | |
| SCHEMBL17011201 | 0.78 | MME (0.65) | MMEACEMMEL1 | |
| SCHEMBL18724746 | 0.78 | MME (0.65) | MMEACEMMEL1 | |
| SCHEMBL18724846 | 0.78 | MME (0.50) | MMEACEMMEL1 | |
| SCHEMBL17011205 | 0.78 | MME (0.50) | MMEACEMMEL1 | |
| SCHEMBL1768194 | 0.78 | GPR34 (0.56) | MMEACEMMEL1 | |
| SCHEMBL1768190 | 0.78 | GPR34 (0.56) | MMEACEMMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3199517-A1 | NEPRILYSIN INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2017-08-02 | — | — | EP | disclosed |