Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14351705 | 0.84 | — | — | |
| SCHEMBL18726230 | 0.76 | PLA2G10 (0.37) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL18039916 | 0.66 | PTGER3 (0.32) | — | |
| SCHEMBL2522106 | 0.62 | PLA2G10 (0.41) | — | |
| SCHEMBL922909 | 0.61 | KMT2A (0.49) | KDM4E | |
| SCHEMBL16357120 | 0.61 | ALDH1A1 (0.42) | KDM4EL3MBTL1 | |
| SCHEMBL23124266 | 0.60 | KDM4E (0.33) | KDM4EL3MBTL1 | |
| SCHEMBL16679707 | 0.60 | HTT (0.43) | — | |
| SCHEMBL14351703 | 0.60 | PLA2G10 (0.39) | — | |
| Hydrochloric Acid SCHEMBL925122 | 0.60 | KMT2A (0.47) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376478-B1 | PYRIDYLOXYINDOLES INHIBITORS OF VEGF-R2 AND USE THEREOF FOR TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2017-04-19 | — | — | EP | disclosed |