Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACR | P10323 | 2/20 | 0.57 |
| ▸ | SNCA | P37840 | 1/20 | 0.56 |
| ▸ | ALPL | P05186 | 9/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | RPA1 | P27694 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23803931 | 0.85 | ALPL (0.73) | ACRSNCAALPLRAB9ANPC1 | |
| SCHEMBL2846632 | 0.83 | ALPL (0.73) | ACRALPLCA12TP53RPA1 | |
| SCHEMBL4638840 | 0.83 | ALPL (0.73) | ACRALPLCA12TP53RPA1 | |
| SCHEMBL29444415 | 0.83 | ALPL (0.73) | ACRSNCAALPLRAB9ACA12 | |
| SCHEMBL2789578 | 0.83 | TP53 (0.74) | ACRALPLCA12TP53RPA1 | |
| SCHEMBL2851298 | 0.83 | SCN9A (0.54) | ACRALPLRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4789868 | 0.81 | CCNC (0.54) | ALPLCA12TP53RPA1MAPT | |
| SCHEMBL855912 | 0.80 | ALPL (0.76) | SNCAALPLRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL20661049 | 0.80 | TP53 (0.51) | ACRALPLRAB9ACA12TP53 | |
| SCHEMBL2848443 | 0.80 | ALPL (0.76) | ACRALPLRAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114057646-B | Pyrazole derivative and application thereof in preparation of antitumor drugs | 常州大学 | 2023-05-02 | — | — | CN | disclosed |
| CN-114057646-A | Pyrazole derivative and application thereof in preparation of antitumor drugs | 常州大学 | 2022-02-18 | — | — | CN | disclosed |
| EP-2376478-B1 | PYRIDYLOXYINDOLES INHIBITORS OF VEGF-R2 AND USE THEREOF FOR TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2017-04-19 | — | — | EP | disclosed |