Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 14/20 | 0.62 |
| ▸ | CHRM2 known ✓ | P08172 | 13/20 | 0.59 |
| ▸ | CHRM1 known ✓ | P11229 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | HRH1 | P35367 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1872734 | 1.00 | CHRM3 (0.62) | CHRM3CHRM2CHRM1RAB9ASLC22A1 | |
| Bromide SCHEMBL1876891 | 0.94 | CHRM3 (0.63) | CHRM3CHRM2CHRM1RAB9ASLC22A1 | |
| Bromide SCHEMBL1879232 | 0.87 | RAB9A (0.75) | CHRM3CHRM2CHRM1RAB9ASLC22A1 | |
| Bromide SCHEMBL1874561 | 0.87 | RAB9A (0.75) | CHRM3CHRM2CHRM1RAB9ASLC22A1 | |
| Bromide SCHEMBL1874562 | 0.87 | RAB9A (0.75) | CHRM3CHRM2CHRM1RAB9ASLC22A1 | |
| Bromide SCHEMBL1087613 | 0.86 | CHRM3 (0.66) | CHRM3CHRM2CHRM1KCNH2CYP2D6 | |
| Bromide SCHEMBL1875236 | 0.86 | CHRM3 (0.62) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Bromide SCHEMBL1875238 | 0.86 | CHRM3 (0.62) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| SCHEMBL3312449 | 0.84 | CHRM3 (0.62) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| SCHEMBL1088393 | 0.81 | CHRM2 (0.55) | CHRM3CHRM2CHRM1RAB9ASLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947730-B2 | Piperidinium and pyrrolidinium derivatives as ligands for the muscarinic M3 receptor | NOVARTIS AG (CH) | 2011-05-24 | — | — | US | disclosed |
| US-20060287362-A1 | Organic compounds | NOVARTIS AG (CH) | 2006-12-21 | — | — | US | disclosed |
| EP-1638940-A2 | PIPERIDINIUM AND PYRROLIDINIUM DERIVATIVES AS LIGANDS FOR THE MUSCARINIC M3 RECEPTOR | Novartis AG (CH) | 2006-03-29 | — | — | EP | disclosed |
| WO-2005000815-A2 | PIPERIDINIUM AND PYRROLIDINIUM DERIVATIVES AS LIGANDS FOR THE MUSCARINIC M3 RECEPTOR | NOVARTIS AG (CH) | 2005-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287362-A1 | Organic compounds | CHRM2, CHRM3, CHRM1 | CHRM3 2/4885CHRM2 1/4885CHRM1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.