Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.58 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18692285 | 0.88 | MEN1 (0.63) | MEN1KMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL28515762 | 0.84 | ALDH1A1 (0.96) | MEN1KMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL17054335 | 0.83 | MAPT (0.49) | MEN1KMT2AALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL31165906 | 0.81 | ALDH1A1 (0.48) | MEN1KMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL21436696 | 0.81 | ALDH1A1 (0.48) | MEN1KMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL6284416 | 0.81 | CYP1A2 (0.68) | MEN1KMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL18692351 | 0.80 | ALDH1A1 (0.71) | MEN1KMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL224624 | 0.77 | CYP1A2 (0.72) | MEN1KMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL8864119 | 0.77 | CYP1A2 (0.72) | MEN1KMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL10929795 | 0.77 | ALDH1A1 (0.71) | MEN1KMT2AALDH1A1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017060873-A1 | SUBSTITUTED PYRAZOLO[3,4-B]PYRIDIN-6-CARBOXYLIC ACIDS AND THEIR USE | AbbVie S.à.r.l. (LU) | 2017-04-13 | — | — | WO | disclosed |