Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.72 |
| ▸ | GAA | P10253 | 4/20 | 0.72 |
| ▸ | MAPT | P10636 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | MPI | P34949 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | GUSB | P08236 | 1/20 | 0.51 |
| ▸ | CD38 | P28907 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3691050 | 0.85 | KDM4E (0.68) | L3MBTL1KDM4EGAAMAPTLMNA | |
| SCHEMBL3691048 | 0.85 | KDM4E (0.68) | L3MBTL1KDM4EGAAMAPTLMNA | |
| SCHEMBL18746290 | 0.84 | L3MBTL1 (1.00) | L3MBTL1KDM4EGAAMAPTLMNA | |
| SCHEMBL18746291 | 0.81 | MAOB (0.74) | L3MBTL1KDM4EGAAMAPTLMNA | |
| SCHEMBL18746293 | 0.81 | GAA (0.72) | L3MBTL1KDM4EGAAMAPTLMNA | |
| SCHEMBL21519432 | 0.80 | POLB (0.66) | L3MBTL1KDM4EGAAMAPTLMNA | |
| SCHEMBL21519523 | 0.80 | POLB (0.66) | L3MBTL1KDM4EGAAMAPTLMNA | |
| SCHEMBL3084339 | 0.79 | GAA (0.79) | L3MBTL1KDM4EGAAMAPTLMNA | |
| SCHEMBL3084344 | 0.79 | GAA (0.79) | L3MBTL1KDM4EGAAMAPTLMNA | |
| SCHEMBL29128745 | 0.78 | L3MBTL1 (0.60) | L3MBTL1KDM4EGAAMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9622993-B2 | Thiosemicarbazones inhibitors of lysophosphatidic acid acyltransferase and uses thereof | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2017-04-18 | — | — | US | disclosed |