Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 4/20 | 0.48 |
| ▸ | SCNN1A | P37088 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18748462 | 0.88 | SCNN1A (0.45) | PLAUSCNN1AALDH1A1KDM4EGLA | |
| SCHEMBL18748452 | 0.86 | SCNN1A (0.46) | SCNN1AALDH1A1KDM4EGLAHPGD | |
| SCHEMBL18748449 | 0.86 | SCNN1A (0.46) | SCNN1AALDH1A1KDM4EGLAHPGD | |
| SCHEMBL18760196 | 0.85 | SCNN1A (0.51) | PLAUSCNN1AALDH1A1KDM4EGLA | |
| SCHEMBL18748442 | 0.85 | SCNN1A (0.53) | PLAUSCNN1AALDH1A1KDM4EGLA | |
| SCHEMBL17108573 | 0.85 | SCNN1A (0.53) | PLAUSCNN1AALDH1A1KDM4EGLA | |
| SCHEMBL18748447 | 0.85 | SCNN1A (0.53) | PLAUSCNN1AALDH1A1KDM4EGLA | |
| SCHEMBL18748444 | 0.83 | SCNN1A (0.49) | PLAUSCNN1AALDH1A1KDM4EGLA | |
| SCHEMBL1428415 | 0.80 | SCNN1A (0.55) | SCNN1AALDH1A1KDM4EGLAHPGD | |
| SCHEMBL11959313 | 0.77 | SCNN1A (0.51) | PLAUSCNN1AALDH1A1KDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10954211-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2021-03-23 | — | — | US | disclosed |
| US-20190330187-A1 | Chemical Compounds | ASTRAZENECA UK LIMITED (GB) | 2019-10-31 | — | — | US | disclosed |
| US-10336725-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2019-07-02 | — | — | US | disclosed |
| US-20180162838-A1 | Chemical Compounds | ASTRAZENECA AB (SE) | 2018-06-14 | — | — | US | disclosed |
| US-20180162838-A1 | Chemical Compounds | ASTRAZENECA AB (SE) | 2018-06-14 | — | — | US | disclosed |
| US-9873678-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2018-01-23 | — | — | US | disclosed |
| US-9873678-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2018-01-23 | — | — | US | disclosed |
| US-20170107195-A1 | Chemical Compounds | ASTRAZENECA AB (SE) | 2017-04-20 | — | — | US | disclosed |
| US-20170107195-A1 | Chemical Compounds | ASTRAZENECA AB (SE) | 2017-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170107195-A1 | Chemical Compounds | CFTR, SCNN1B, SCNN1A | PLAU 4370/4885SCNN1A 3/4885ALDH1A1 933/4885 |
| US-10336725-B2 | Chemical compounds | CFTR, SCNN1B, SCNN1A | PLAU 4370/4885SCNN1A 3/4885ALDH1A1 933/4885 |
| US-20180162838-A1 | Chemical Compounds | CFTR, SCNN1B, SCNN1A | PLAU 4370/4885SCNN1A 3/4885ALDH1A1 933/4885 |
| US-10954211-B2 | Chemical compounds | CFTR, SCNN1B, SCNN1A | PLAU 4370/4885SCNN1A 3/4885ALDH1A1 933/4885 |
| US-20190330187-A1 | Chemical Compounds | CFTR, SCNN1B, SCNN1A | PLAU 4370/4885SCNN1A 3/4885ALDH1A1 933/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.