Dolastatin 15

Dolastatin 15

SCHEMBL187502

COC1=CC(=O)N(C(=O)[C@@H](OC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C)C(C)C)C(C)C)[C@H]1Cc1ccccc1

nearest known ligand 0.74

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CTSD P07339 10/20 0.36
CTSE P14091 10/20 0.36
BACE1 P56817 7/20 0.36
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
ALDH1A1 P00352 1/20 0.33
CYP3A4 P08684 1/20 0.33
TSHR P16473 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dolastatin 15 SCHEMBL12377885 1.00 CTSD (0.36) CTSDCTSEBACE1MEN1KMT2A
Dolastatin 15 SCHEMBL4357916 1.00 CTSD (0.36) CTSDCTSEBACE1MEN1KMT2A
Dolastatin 15 SCHEMBL13542771 1.00 CTSD (0.36) CTSDCTSEBACE1MEN1KMT2A
Dolastatin 15 SCHEMBL14363293 1.00 CTSD (0.36) CTSDCTSEBACE1MEN1KMT2A
Dolastatin 15 SCHEMBL14389122 1.00 CTSD (0.36) CTSDCTSEBACE1MEN1KMT2A
Dolastatin 15 SCHEMBL19570274 1.00 CTSD (0.36) CTSDCTSEBACE1MEN1KMT2A
Dolastatin 15 SCHEMBL12361466 1.00 CTSD (0.36) CTSDCTSEBACE1MEN1KMT2A
SCHEMBL16801885 0.94 CTSD (0.36) CTSDCTSEBACE1MEN1KMT2A
SCHEMBL19302617 0.93 MEN1 (0.38) MEN1KMT2A
SCHEMBL19302613 0.93 MEN1 (0.38) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2039 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260091119-A1 ISOLATED TARGETED DELIVERY SYSTEM FOR THE TREATMENT OF GLIOMA CELLIS AG (CH) 2026-04-02 US claimed
EP-4637829-A1 ISOLATED TARGETED DELIVERY SYSTEM FOR THE TREATMENT OF OVARIAN CANCER Cellis Sp. z o.o. ([Ltd.] (PL) 2025-10-29 EP claimed
US-20250325717-A1 ANTI-NUCLEOPHOSMIN 1 ANTIBODY AND ANTIBODY CONJUGATE COMBINATION THERAPIES THE CHILDREN'S MEDICAL CENTER CORPORATION (US) 2025-10-23 US claimed
US-20250313647-A1 MUTANT AND MISLOCALIZED CELL SURFACE NUCLEOPHOSMIN 1 AS A DIAGNOSTIC AND THERAPEUTIC TARGET OF HUMAN DISEASE THE CHILDREN'S MEDICAL CENTER CORPORATION (US) 2025-10-09 US claimed
US-20250276084-A1 HYDROPHILIC LINKERS AND CONJUGATES THEREOF GLYKOS FINLAND OY (FI) 2025-09-04 US claimed
US-12398172-B2 Therapeutic oligonucleotides CARIS SCIENCE, INC. (US) 2025-08-26 US claimed
EP-4313156-B1 DISULFIDE-BASED PRODRUG COMPOUNDS UNIV MUENCHEN LUDWIG MAXIMILIANS (DE) 2025-08-06 EP claimed
EP-4587062-A1 ISOLATED TARGETED DELIVERY SYSTEM FOR THE TREATMENT OF GLIOMA Cellis AG (CH) 2025-07-23 EP claimed
CN-120192413-A Antibody targeting FR alpha or antibody coupling drug and application thereof 三优生物医药(上海)有限公司 2025-06-24 CN claimed
US-20250177546-A1 ROR1-TARGETED BINDING MOLECULE AND USE THEREOF HANGZHOU ZHONGMEIHUADONG PHARMACEUTICAL CO., LTD. (CN) 2025-06-05 US claimed
WO-2002015700-A1 PRODRUGS ACTIVATED BY PLASMIN AND THEIR USE IN CANCER CHEMOTHERAPY COULTER PHARMACEUTICAL, INC. (US) 2002-02-28 WO claimed
EP-1049481-A4 SYNTHETIC ANTINEOPLASTIC AGENTS DERIVED FROM DOLASTATIN 15 AND METHODS OF MAKING SAME UNIV ARIZONA (US) 2001-09-12 EP claimed
WO-2001024763-A2 COMPOSITIONS AND METHODS FOR TREATING CANCER USING IMMUNOCONJUGATES AND CHEMOTHERAPEUTIC AGENTS IMMUNOGEN, INC. (US) 2001-04-12 WO claimed
EP-1049481-A2 SYNTHETIC ANTINEOPLASTIC AGENTS DERIVED FROM DOLASTATIN 15 AND METHODS OF MAKING SAME ARIZONA BOARD OF REGENTS (US) 2000-11-08 EP claimed
EP-0842190-B1 PROCESS FOR PRODUCING DOLASTATIN 15 AND INTERMEDIATES THEREOF BASF AG (DE) 1999-10-06 EP claimed
WO-1999015130-A2 SYNTHETIC ANTINEOPLASTIC AGENTS DERIVED FROM DOLASTATIN 15 AND METHODS OF MAKING SAME ARIZONA BOARD OF REGENTS, actingon behalf of ARIZ ONA STATE UNIVERSITY (US) 1999-04-01 WO claimed
EP-0842190-A1 PROCESS FOR PRODUCING DOLASTATIN 15 AND INTERMEDIATES THEREOF BASF AKTIENGESELLSCHAFT (DE) 1998-05-20 EP claimed
WO-1997005162-A1 PROCESS FOR PRODUCING DOLASTATIN 15 AND INTERMEDIATES THEREOF BASF AKTIENGESELLSCHAFT (DE) 1997-02-13 WO claimed
US-5554725-A Synthesis of dolastatin 15 ARIZONA BOARD OF REGENTS ACTING ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 1996-09-10 US claimed
US-4879278-A ANTINEOPLASTIC ARIZONA BOARD OF REGENTS (US) 1989-11-07 US claimed