SCHEMBL1875182

SCHEMBL1875182

O=C(O)C1=C(C(=O)NO)CCCC1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 7/20 0.44
NPSR1 Q6W5P4 1/20 0.44
HDAC4 P56524 2/20 0.42
HDAC2 Q92769 2/20 0.42
HDAC8 Q9BY41 2/20 0.42
HDAC6 Q9UBN7 2/20 0.42
PARP1 P09874 1/20 0.40
PARP15 Q460N3 1/20 0.40
PARP10 Q53GL7 1/20 0.40
LMNA P02545 1/20 0.40
HDAC3 O15379 1/20 0.39
HDAC1 Q13547 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
HDAC5 Q9UQL6 1/20 0.39
FABP4 P15090 3/20 0.38
FABP5 Q01469 3/20 0.38
SLC6A2 P23975 1/20 0.36
SLC6A4 P31645 1/20 0.36
SLC6A3 Q01959 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17024326 0.82 DHODH (0.41) DHODHNPSR1PARP1PARP15PARP10
SCHEMBL12491707 0.82 DHODH (0.41) DHODHNPSR1PARP1PARP15PARP10
SCHEMBL28247062 0.82 DHODH (0.41) DHODHNPSR1PARP1PARP15PARP10
SCHEMBL217840 0.82 DHODH (0.41) DHODHNPSR1PARP1PARP15PARP10
SCHEMBL5415654 0.82 DHODH (0.41) DHODHNPSR1PARP1PARP15PARP10
SCHEMBL12491709 0.82 DHODH (0.41) DHODHNPSR1PARP1PARP15PARP10
SCHEMBL17024327 0.82 DHODH (0.41) DHODHNPSR1PARP1PARP15PARP10
SCHEMBL23664366 0.79 DHODH (0.43) DHODHNPSR1PARP1PARP15PARP10
SCHEMBL6740335 0.79 DHODH (0.39) DHODHNPSR1PARP1PARP15PARP10
Bromide SCHEMBL689744 0.79 DHODH (0.39) DHODHNPSR1PARP1PARP15PARP10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011057110-A1 GPR109A AGONISTS FOR THE TREATMENT OF CEREBRAL ISCHEMIA RUPRECHT-KARLS-UNIVERSITAT-HEIDELBERG (DE) 2011-05-12 WO disclosed