Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C8 | P10632 | 6/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL119435 | 0.89 | CYP2C8 (0.61) | CYP2C8KCNH2CYP3A4NR1I2 | |
| SCHEMBL120775 | 0.82 | CYP2C8 (0.63) | CYP2C8KCNH2CYP3A4NR1I2 | |
| SCHEMBL19401445 | 0.81 | CYP2C8 (0.55) | CYP2C8KCNH2CYP3A4NR1I2ABL1 | |
| SCHEMBL12330957 | 0.81 | CYP2C8 (0.51) | CYP2C8KCNH2CYP3A4NR1I2ABL1 | |
| SCHEMBL19401368 | 0.80 | CYP2C8 (0.55) | CYP2C8KCNH2CYP3A4NR1I2ABL1 | |
| SCHEMBL119462 | 0.79 | CYP2C8 (0.74) | CYP2C8KCNH2CYP3A4NR1I2ABL1 | |
| SCHEMBL119399 | 0.78 | CYP2C8 (0.59) | CYP2C8KCNH2CYP3A4NR1I2 | |
| SCHEMBL143315 | 0.77 | CYP2C8 (0.60) | CYP2C8KCNH2CYP3A4NR1I2 | |
| SCHEMBL120472 | 0.76 | CYP2C8 (0.59) | CYP2C8KCNH2CYP3A4NR1I2 | |
| SCHEMBL120828 | 0.74 | CYP2C8 (0.77) | CYP2C8KCNH2CYP3A4NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2545051-B1 | COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | BRISTOL MYERS SQUIBB CO (US) | 2017-04-19 | — | — | EP | disclosed |