Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C8 | P10632 | 6/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19401368 | 0.91 | CYP2C8 (0.55) | CYP2C8KCNH2CYP3A4NR1I2ABL1 | |
| SCHEMBL19401316 | 0.90 | CYP2C8 (0.68) | CYP2C8KCNH2CYP3A4NR1I2ABL1 | |
| SCHEMBL19385895 | 0.88 | CYP2C8 (0.71) | CYP2C8KCNH2CYP3A4NR1I2 | |
| SCHEMBL12330957 | 0.84 | CYP2C8 (0.51) | CYP2C8KCNH2CYP3A4NR1I2ABL1 | |
| SCHEMBL2143062 | 0.81 | CYP2C8 (0.82) | CYP2C8KCNH2CYP3A4NR1I2 | |
| SCHEMBL19401443 | 0.81 | CYP2C8 (0.67) | CYP2C8KCNH2CYP3A4NR1I2ABL1 | |
| SCHEMBL19401314 | 0.81 | CYP2C8 (0.69) | CYP2C8KCNH2CYP3A4NR1I2 | |
| SCHEMBL18752129 | 0.81 | CYP2C8 (0.47) | CYP2C8KCNH2CYP3A4NR1I2ABL1 | |
| SCHEMBL15285746 | 0.80 | CYP2C8 (0.72) | CYP2C8KCNH2CYP3A4NR1I2 | |
| SCHEMBL9899509 | 0.80 | CYP2C8 (0.72) | CYP2C8KCNH2CYP3A4NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017165233-A1 | BENZOFURAN DERIVATIVES FOR THE TREATMENT OF HEPATITIS C | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-09-28 | — | — | WO | disclosed |