Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 15/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.37 |
| ▸ | RPTOR | Q8N122 | 9/20 | 0.37 |
| ▸ | MLST8 | Q9BVC4 | 9/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.32 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27392472 | 0.73 | MEN1 (0.44) | CRBNCYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL135934 | 0.72 | MTOR (0.65) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL12232733 | 0.72 | CRBN (0.41) | CRBNMTORPIK3CACYP11B1CYP11B2 | |
| SCHEMBL25462260 | 0.72 | CRBN (0.41) | CRBNMTORPIK3CACYP11B1CYP11B2 | |
| SCHEMBL25462578 | 0.72 | CRBN (0.41) | CRBNCYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL23889656 | 0.72 | MEN1 (0.33) | MEN1KMT2A | |
| SCHEMBL135898 | 0.72 | MTOR (0.73) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL5847527 | 0.70 | CRBN (0.42) | CRBNMTORRPTORMLST8CYP11B1 | |
| SCHEMBL17813469 | 0.69 | MEN1 (0.44) | MEN1KMT2A | |
| SCHEMBL12394683 | 0.68 | KDR (0.40) | CRBNCSF1RMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2457913-B1 | Heteroaryl compounds, compositions thereof, and methods of treatment therewith | SIGNAL PHARM LLC (US) | 2017-04-19 | — | — | EP | disclosed |