Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.80 |
| ▸ | KDR | P35968 | 19/20 | 0.80 |
| ▸ | IGF1R | P08069 | 17/20 | 0.80 |
| ▸ | MST1R | Q04912 | 2/20 | 0.67 |
| ▸ | AXL | P30530 | 1/20 | 0.66 |
| ▸ | AURKA | O14965 | 1/20 | 0.66 |
| ▸ | JAK2 | O60674 | 1/20 | 0.66 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.66 |
| ▸ | ABL1 | P00519 | 1/20 | 0.66 |
| ▸ | INSR | P06213 | 1/20 | 0.66 |
| ▸ | LCK | P06239 | 1/20 | 0.66 |
| ▸ | RET | P07949 | 1/20 | 0.66 |
| ▸ | KIT | P10721 | 1/20 | 0.66 |
| ▸ | PIM1 | P11309 | 1/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.66 |
| ▸ | SRC | P12931 | 1/20 | 0.66 |
| ▸ | PRKACA | P17612 | 1/20 | 0.66 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.66 |
| ▸ | JAK1 | P23458 | 1/20 | 0.66 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL198251 | 0.89 | MET (0.89) | METKDRIGF1RMST1RAXL | |
| SCHEMBL199381 | 0.89 | MET (1.00) | METKDRIGF1RMST1RAXL | |
| SCHEMBL783470 | 0.89 | MET (0.89) | METKDRIGF1RMST1RAXL | |
| SCHEMBL783635 | 0.86 | MET (0.84) | METKDRIGF1RMST1RAXL | |
| SCHEMBL198520 | 0.86 | MET (0.82) | METKDRIGF1RMST1RAXL | |
| SCHEMBL199844 | 0.85 | MET (0.86) | METKDRIGF1RMST1RAXL | |
| SCHEMBL783490 | 0.85 | MET (0.81) | METKDRIGF1RMST1RAXL | |
| SCHEMBL783488 | 0.85 | MET (0.79) | METKDRIGF1RMST1RAXL | |
| SCHEMBL783491 | 0.85 | MET (0.86) | METKDRIGF1RMST1RAXL | |
| SCHEMBL13467750 | 0.84 | MET (0.76) | METKDRIGF1RMST1RAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2532657-B9 | Compounds and methods of use | SUNSHINE LAKE PHARMA CO LTD (CN) | 2017-04-19 | — | — | EP | disclosed |