Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | IRAK4 | Q9NWZ3 | 10/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18757491 | 1.00 | HSD11B1 (0.58) | HSD11B1HSD17B10KDM4EIRAK4HTT | |
| SCHEMBL30009908 | 0.86 | HSD11B1 (0.61) | HSD11B1HSD17B10KDM4EIRAK4HTT | |
| SCHEMBL18754643 | 0.84 | KDM4E (0.66) | HSD11B1HSD17B10KDM4EIRAK4HTT | |
| SCHEMBL18757492 | 0.84 | KDM4E (0.66) | HSD11B1HSD17B10KDM4EIRAK4HTT | |
| SCHEMBL21689538 | 0.84 | KDM4E (0.66) | HSD11B1HSD17B10KDM4EIRAK4HTT | |
| SCHEMBL18732210 | 0.84 | KDM4E (0.66) | HSD11B1HSD17B10KDM4EIRAK4HTT | |
| SCHEMBL22947094 | 0.83 | KDM4E (0.67) | HSD11B1HSD17B10KDM4EIRAK4HTT | |
| SCHEMBL14368750 | 0.81 | HSD11B1 (0.53) | HSD11B1HSD17B10KDM4EIRAK4HTT | |
| SCHEMBL31572582 | 0.80 | HSD11B1 (0.58) | HSD11B1HSD17B10KDM4EIRAK4JAK2 | |
| SCHEMBL30010027 | 0.77 | HSD11B1 (0.61) | HSD11B1HSD17B10KDM4EIRAK4HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3156405-A1 | SPIROCYCLIC ETHER DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE | Boehringer Ingelheim International GmbH (DE) | 2017-04-19 | — | — | EP | disclosed |