Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 9/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17440089 | 0.91 | AXL (0.40) | USP30CHRM1AXLMERTKPDE2A | |
| SCHEMBL18725472 | 0.88 | AXL (0.41) | USP30CHRM1AXLMERTKPDE2A | |
| SCHEMBL17440098 | 0.87 | GABRP (0.42) | USP30CHRM1AXLMERTKPDE2A | |
| SCHEMBL18725478 | 0.80 | CHRM1 (0.64) | CHRM1AXLMERTKPDE2APDE11A | |
| SCHEMBL18725408 | 0.79 | CHRM1 (0.66) | CHRM1AXLMERTKPDE2APDE11A | |
| Hydrochloric Acid SCHEMBL18725413 | 0.79 | CHRM1 (0.63) | CHRM1AXLMERTKPDE2APDE11A | |
| SCHEMBL18756656 | 0.79 | CHRM1 (0.44) | USP30CHRM1AXLMERTKPDE2A | |
| SCHEMBL17449677 | 0.77 | CHRM1 (0.70) | CHRM1PDE2APDE11A | |
| SCHEMBL17440017 | 0.77 | CHRM1 (0.70) | CHRM1PDE2APDE11A | |
| SCHEMBL17443033 | 0.77 | CHRM1 (0.56) | USP30CHRM1AXLMERTKPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3156397-B1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2019-08-07 | — | — | EP | disclosed |
| EP-3156397-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2017-04-19 | — | — | EP | disclosed |