Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | BCL6 | P41182 | 2/20 | 0.41 |
| ▸ | CAMK1D | Q8IU85 | 2/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18757833 | 0.73 | BRD4 (0.53) | ABCG2GRM4SYKEGFRCAMK1D | |
| SCHEMBL30177167 | 0.73 | ABCG2 (0.46) | BRAFABCG2GRM4SYKKDM4E | |
| SCHEMBL30069223 | 0.71 | SYK (0.51) | ABCG2GRM4SYKEGFRKDR | |
| SCHEMBL12279158 | 0.69 | BRD4 (0.56) | ABCG2GRM4SYKEGFRCAMK1D | |
| SCHEMBL4131488 | 0.69 | KDM4E (0.59) | BRAFABCG2SYKKDM4EEGFR | |
| SCHEMBL12111163 | 0.69 | BRD4 (0.59) | ABCG2GRM4SYKEGFRCAMK1D | |
| SCHEMBL21625856 | 0.69 | KIF11 (0.54) | ABCG2GRM4EGFR | |
| SCHEMBL29514710 | 0.69 | KIF11 (0.54) | ABCG2GRM4EGFR | |
| SCHEMBL12266446 | 0.69 | MAPT (0.53) | ABCG2GRM4KDM4EEGFRKDR | |
| SCHEMBL17526197 | 0.69 | BRD4 (0.58) | ABCG2GRM4BCL6BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017066428-A1 | BRD4-KINASE INHIBITORS AS CANCER THERAPEUTICS | H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, INC. (US) | 2017-04-20 | — | — | WO | disclosed |