Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.50 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | F13A1 | P00488 | 1/20 | 0.48 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
| ▸ | TGM1 | P22735 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4243010 | 0.85 | ALDH1A1 (0.73) | ALDH1A1MAPTNPC1RAB9AMAPK1 | |
| SCHEMBL16976307 | 0.84 | ALDH1A1 (0.65) | ALDH1A1MAPTNPC1RAB9AMAPK1 | |
| SCHEMBL4240888 | 0.83 | ALDH1A1 (0.64) | ALDH1A1MAPTNPC1RAB9AMAPK1 | |
| SCHEMBL25273779 | 0.82 | ALDH1A1 (0.69) | ALDH1A1MAPTNPC1RAB9AMAPK1 | |
| SCHEMBL22324899 | 0.82 | DDB1 (0.67) | MAPTPTPN2PTPN1PTPN6GPR119 | |
| SCHEMBL2774486 | 0.82 | ALDH1A1 (0.56) | ALDH1A1MAPTNPC1RAB9AMAPK1 | |
| SCHEMBL29716436 | 0.81 | ALDH1A1 (0.61) | ALDH1A1MAPTNPC1RAB9AMAPK1 | |
| SCHEMBL31180977 | 0.81 | ALDH1A1 (0.61) | ALDH1A1MAPTNPC1RAB9AMAPK1 | |
| SCHEMBL595609 | 0.81 | ALDH1A1 (0.57) | ALDH1A1MAPTNPC1RAB9AMAPK1 | |
| SCHEMBL2419028 | 0.81 | ALDH1A1 (0.57) | ALDH1A1MAPTNPC1RAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7939661-B2 | Antidiabetic agents; somatostatin receptor subtype 5 modulators; noninsulin dependent diabetes mellitus; side effect reduction; synthesis | HOFFMAN-LA ROCHE INC. (US) | 2011-05-10 | — | — | US | disclosed |
| CN-101511817-A | Pyridine-and quinoline-pyrimidine derivatives | HOFFMANN LA ROCHE (CH) | 2009-08-19 | — | — | CN | disclosed |
| US-20080064697-A1 | PYRIDINE, QUINOLINE AND PYRIMIDINE DERIVATIVES | HOFFMAN-LA ROCHE INC. | 2008-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064697-A1 | PYRIDINE, QUINOLINE AND PYRIMIDINE DERIVATIVES | SSTR5, SSTR3, NPY5R | ALDH1A1 1558/4885MAPT 4308/4885NPC1 3153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.