SCHEMBL18758271

SCHEMBL18758271

COc1cc(C(C)=O)ccc1OI

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.58
CYP1A2 P05177 1/20 0.58
CYP3A4 P08684 1/20 0.58
CYP2C9 P11712 1/20 0.58
CYP2C19 P33261 1/20 0.58
CA12 O43570 1/20 0.56
CA1 P00915 1/20 0.56
CA2 P00918 1/20 0.56
CA4 P22748 1/20 0.56
CA6 P23280 1/20 0.56
CA7 P43166 1/20 0.56
TPMT P51580 1/20 0.56
CA9 Q16790 1/20 0.56
CA14 Q9ULX7 1/20 0.56
ALDH1A1 P00352 4/20 0.55
KMT2A Q03164 3/20 0.54
LMNA P02545 1/20 0.53
MEN1 O00255 2/20 0.53
SMN1; SMN2 Q16637 3/20 0.52
L3MBTL1 Q9Y468 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29399077 0.88 TSHR (0.73) TSHRCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL27753902 0.88 TSHR (0.73) TSHRCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL76834 0.88 TSHR (0.73) TSHRCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL21758122 0.83 TSHR (0.60) TSHRCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL2997461 0.81 TSHR (0.77) TSHRCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL12554574 0.81 TSHR (0.58) TSHRCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL8117596 0.81 TSHR (0.58) TSHRCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL27781532 0.80 TSHR (0.61) TSHRCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL7943307 0.79 ALDH1A1 (0.54) TSHRCYP1A2CYP3A4CYP2C9CYP2C19
Apocynin SCHEMBL28029251 0.79 MEN1 (0.72) CYP1A2ALDH1A1KMT2ALMNAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017063755-A1 CONFORMATIONALLY CONSTRAINED MACROCYCLIC COMPOUNDS POLYPHOR AG (CH) 2017-04-20 WO disclosed
WO-2017063754-A1 CONFORMATIONALLY CONSTRAINED MACROCYCLIC COMPOUNDS AS PIN1 MODULATORS POLYPHOR AG (CH) 2017-04-20 WO disclosed