Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 11/20 | 0.54 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | PGR | P06401 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18758226 | 0.82 | ATM (0.46) | ARSIRT6LMNASMN1; SMN2HPGD | |
| SCHEMBL29229681 | 0.82 | AR (0.66) | ARSIRT6LMNASMN1; SMN2HPGD | |
| SCHEMBL29229651 | 0.81 | AR (0.57) | ARSIRT6LMNASMN1; SMN2HPGD | |
| SCHEMBL29229645 | 0.79 | AR (0.63) | ARSIRT6LMNASMN1; SMN2HPGD | |
| SCHEMBL30506378 | 0.79 | AR (0.54) | ARSIRT6LMNASMN1; SMN2HPGD | |
| SCHEMBL23701930 | 0.78 | AR (0.62) | ARSIRT6LMNASMN1; SMN2HPGD | |
| SCHEMBL29229670 | 0.78 | AR (0.70) | ARSIRT6LMNASMN1; SMN2HPGD | |
| SCHEMBL28983834 | 0.77 | HTT (0.46) | LMNASMN1; SMN2HPGDCYP3A4MEN1 | |
| SCHEMBL18758228 | 0.76 | NOTUM (0.38) | AR | |
| SCHEMBL23714051 | 0.74 | AR (0.55) | ARSIRT6LMNASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10874646-B2 | Epothilone analogs, methods of synthesis, methods of treatment, and drug conjugates thereof | WILLIAM MARSH RICE UNIVERSITY (US) | 2020-12-29 | — | — | US | disclosed |
| US-20190022069-A1 | EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES THEREOF | WILLIAM MARSH RICE UNIVERSITY (US) | 2019-01-24 | — | — | US | disclosed |
| WO-2017066606-A1 | EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES THEREOF | WILLIAM MARSH RICE UNIVERSITY (US) | 2017-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10874646-B2 | Epothilone analogs, methods of synthesis, methods of treatment, and drug conjugates thereof | EPOR, CD47, DHPS | AR 1330/4885SIRT6 3036/4885LMNA 2828/4885 |
| US-20190022069-A1 | EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES THEREOF | EPOR, CD47, DHPS | AR 1330/4885SIRT6 3036/4885LMNA 2828/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.