Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.34 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL295558 | 0.77 | MAPK1 (0.42) | MAPK1MMP2MMP13MMP14BAZ2B | |
| SCHEMBL69696 | 0.77 | MEN1 (0.44) | MAPK1BAZ2BKDM4EALDH1A1HPGD | |
| SCHEMBL2246566 | 0.77 | BAZ2B (0.62) | MAPK1MMP2MMP13MMP14BAZ2B | |
| SCHEMBL24915278 | 0.75 | MEN1 (0.42) | MAPK1MMP2MMP13MMP14BAZ2B | |
| SCHEMBL478715 | 0.75 | MAPK1 (0.41) | MAPK1MMP2MMP13MMP14BAZ2B | |
| SCHEMBL1312902 | 0.75 | MAPK1 (0.44) | MAPK1MMP2MMP13MMP14BAZ2B | |
| SCHEMBL1312720 | 0.75 | MAPK1 (0.41) | MAPK1MMP2MMP13MMP14BAZ2B | |
| SCHEMBL1314210 | 0.75 | MAPT (0.41) | MAPK1MMP2MMP13MMP14BAZ2B | |
| Hydrochloric Acid SCHEMBL25408530 | 0.74 | MAPK1 (0.40) | MAPK1MMP2MMP13MMP14BAZ2B | |
| SCHEMBL1267336 | 0.74 | KDM4E (0.50) | MAPK1KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210238187-A1 | AZIRIDINE CONTAINING EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES | WILLIAM MARSH RICE UNIVERSITY (US) | 2021-08-05 | — | — | US | disclosed |
| US-20210238187-A1 | AZIRIDINE CONTAINING EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES | WILLIAM MARSH RICE UNIVERSITY (US) | 2021-08-05 | — | — | US | disclosed |
| US-10874646-B2 | Epothilone analogs, methods of synthesis, methods of treatment, and drug conjugates thereof | WILLIAM MARSH RICE UNIVERSITY (US) | 2020-12-29 | — | — | US | disclosed |
| US-20190022069-A1 | EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES THEREOF | WILLIAM MARSH RICE UNIVERSITY (US) | 2019-01-24 | — | — | US | disclosed |
| WO-2017066606-A1 | EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES THEREOF | WILLIAM MARSH RICE UNIVERSITY (US) | 2017-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10874646-B2 | Epothilone analogs, methods of synthesis, methods of treatment, and drug conjugates thereof | EPOR, CD47, DHPS | MAPK1 4152/4885MMP2 2340/4885MMP13 3580/4885 |
| US-20190022069-A1 | EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES THEREOF | EPOR, CD47, DHPS | MAPK1 4152/4885MMP2 2340/4885MMP13 3580/4885 |
| US-20210238187-A1 | AZIRIDINE CONTAINING EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES | EPOR, EZR, CD47 | MAPK1 4106/4885MMP2 2994/4885MMP13 4257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.