Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12374287 | 0.82 | HPGD (0.37) | — | |
| SCHEMBL18758466 | 0.80 | BCHE (0.32) | BCHE | |
| SCHEMBL18758470 | 0.73 | — | — | |
| SCHEMBL243540 | 0.72 | — | — | |
| SCHEMBL27942728 | 0.72 | BCHE (0.38) | BCHEPOLBMAPT | |
| SCHEMBL24915146 | 0.71 | — | — | |
| SCHEMBL17596006 | 0.71 | — | — | |
| SCHEMBL21792131 | 0.71 | — | — | |
| SCHEMBL7981598 | 0.71 | — | — | |
| SCHEMBL1292950 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210238187-A1 | AZIRIDINE CONTAINING EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES | WILLIAM MARSH RICE UNIVERSITY (US) | 2021-08-05 | — | — | US | disclosed |
| US-20210238187-A1 | AZIRIDINE CONTAINING EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES | WILLIAM MARSH RICE UNIVERSITY (US) | 2021-08-05 | — | — | US | disclosed |
| US-10874646-B2 | Epothilone analogs, methods of synthesis, methods of treatment, and drug conjugates thereof | WILLIAM MARSH RICE UNIVERSITY (US) | 2020-12-29 | — | — | US | disclosed |
| US-20190022069-A1 | EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES THEREOF | WILLIAM MARSH RICE UNIVERSITY (US) | 2019-01-24 | — | — | US | disclosed |
| WO-2017066606-A1 | EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES THEREOF | WILLIAM MARSH RICE UNIVERSITY (US) | 2017-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10874646-B2 | Epothilone analogs, methods of synthesis, methods of treatment, and drug conjugates thereof | EPOR, CD47, DHPS | BCHE 2143/4885POLB 3065/4885MAPT 3333/4885 |
| US-20190022069-A1 | EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES THEREOF | EPOR, CD47, DHPS | BCHE 2143/4885POLB 3065/4885MAPT 3333/4885 |
| US-20210238187-A1 | AZIRIDINE CONTAINING EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES | EPOR, EZR, CD47 | BCHE 1561/4885POLB 4254/4885MAPT 4222/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.