Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.42 |
| ▸ | JAK1 | P23458 | 9/20 | 0.42 |
| ▸ | JAK3 | P52333 | 9/20 | 0.42 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 4/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18759694 | 1.00 | JAK2 (0.42) | JAK2JAK1JAK3IRAK1PIM1 | |
| SCHEMBL12539771 | 0.89 | IRAK1 (0.40) | JAK2JAK1JAK3IRAK1PIM1 | |
| SCHEMBL18759691 | 0.87 | IRAK4 (0.38) | JAK2JAK1JAK3MAPK8IRAK4 | |
| SCHEMBL18759689 | 0.84 | CTSK (0.38) | JAK2JAK1JAK3IRAK1IRAK4 | |
| SCHEMBL2234475 | 0.83 | PIM1 (0.46) | JAK2JAK1JAK3IRAK1PIM1 | |
| SCHEMBL2234477 | 0.83 | PIM1 (0.46) | JAK2JAK1JAK3IRAK1PIM1 | |
| SCHEMBL12539996 | 0.81 | JAK2 (0.50) | JAK2JAK1JAK3 | |
| SCHEMBL12539993 | 0.81 | JAK2 (0.50) | JAK2JAK1JAK3 | |
| SCHEMBL18759715 | 0.78 | JAK2 (0.39) | JAK2JAK1JAK3 | |
| SCHEMBL2364314 | 0.76 | PIM1 (0.51) | IRAK1PIM1PIM2PIK3CGFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493895-B1 | N-CONTAINING HETEROARYL DERIVATIVES AS JAK3 KINASE INHIBITORS | VECTURA LTD (GB) | 2017-04-26 | — | — | EP | disclosed |