Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 19/20 | 0.45 |
| ▸ | JAK2 | O60674 | 18/20 | 0.45 |
| ▸ | JAK1 | P23458 | 13/20 | 0.45 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18759701 | 1.00 | JAK3 (0.45) | JAK3JAK2JAK1EGLN2 | |
| SCHEMBL18759711 | 0.89 | PIM1 (0.41) | JAK3JAK2JAK1 | |
| SCHEMBL18759713 | 0.89 | PIM1 (0.41) | JAK3JAK2JAK1 | |
| SCHEMBL12539996 | 0.88 | JAK2 (0.50) | JAK3JAK2JAK1EGLN2 | |
| SCHEMBL12539993 | 0.88 | JAK2 (0.50) | JAK3JAK2JAK1EGLN2 | |
| SCHEMBL2348268 | 0.85 | EGLN2 (0.49) | JAK3JAK2JAK1EGLN2 | |
| SCHEMBL2362885 | 0.80 | IRAK4 (0.46) | JAK3JAK2JAK1EGLN2 | |
| SCHEMBL2234535 | 0.80 | EGLN2 (0.51) | JAK3JAK2JAK1EGLN2 | |
| SCHEMBL15167072 | 0.80 | JAK2 (0.51) | JAK3JAK2JAK1EGLN2 | |
| SCHEMBL12539525 | 0.79 | PIM1 (0.39) | JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493895-B1 | N-CONTAINING HETEROARYL DERIVATIVES AS JAK3 KINASE INHIBITORS | VECTURA LTD (GB) | 2017-04-26 | — | — | EP | disclosed |