Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.46 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 11/20 | 0.43 |
| ▸ | JAK3 | P52333 | 11/20 | 0.43 |
| ▸ | JAK1 | P23458 | 10/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2348268 | 0.94 | EGLN2 (0.49) | EGLN2JAK2JAK3JAK1CCNT1 | |
| SCHEMBL2345601 | 0.88 | IRAK4 (0.57) | IRAK4FLT3CCNT1 | |
| SCHEMBL2345606 | 0.88 | IRAK4 (0.57) | IRAK4FLT3CCNT1 | |
| SCHEMBL15167072 | 0.88 | JAK2 (0.51) | EGLN2JAK2JAK3JAK1 | |
| SCHEMBL2346126 | 0.84 | JAK1 (0.49) | JAK2JAK3JAK1 | |
| SCHEMBL2346123 | 0.84 | JAK1 (0.49) | JAK2JAK3JAK1 | |
| SCHEMBL2345343 | 0.84 | JAK3 (0.58) | JAK2JAK3JAK1 | |
| SCHEMBL15167182 | 0.84 | JAK3 (0.58) | JAK2JAK3JAK1 | |
| SCHEMBL2234535 | 0.81 | EGLN2 (0.51) | EGLN2JAK2JAK3JAK1 | |
| SCHEMBL18759698 | 0.80 | JAK3 (0.45) | EGLN2JAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011101161-A1 | PYRAZOLE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2011-08-25 | — | — | WO | disclosed |