⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL969840 | 0.89 | — | — | |
| SCHEMBL3671124 | 0.89 | — | — | |
| Acetic Acid SCHEMBL869816 | 0.82 | FFAR3 (0.35) | — | |
| Methylene Chloride SCHEMBL4227657 | 0.81 | — | — | |
| SCHEMBL14321411 | 0.81 | TTR (0.33) | — | |
| SCHEMBL3309034 | 0.78 | — | — | |
| SCHEMBL9587324 | 0.78 | — | — | |
| SCHEMBL713166 | 0.76 | — | — | |
| Methacrylic Acid SCHEMBL15739028 | 0.75 | — | — | |
| SCHEMBL712104 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110218225-A1 | NON-STEROIDAL LIGANDS FOR THE GLUCOCORTICOID RECEPTOR, COMPOSITIONS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-09-08 | — | — | US | disclosed |
| US-7947726-B2 | Non-steroidal ligands for the glucocorticoid receptor, and compositions thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-05-24 | — | — | US | disclosed |
| US-20090137655-A1 | Non-Steroidal Ligands for the Glucocorticoid Receptor, Compositions and Uses Thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-05-28 | — | — | US | disclosed |
| US-7485660-B2 | Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-02-03 | — | — | US | disclosed |
| US-20050054700-A1 | Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2005-03-10 | — | — | US | disclosed |
| US-6831093-B2 | For selectively modulating the activation, repression, agonism and antagonism effects of the glucocorticoid receptor in a patient; for therapy and prophylaxis of obesity, diabetes, depression, neurodegeneration or an inflammatory disease | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2004-12-14 | — | — | US | disclosed |
| EP-1467730-A1 | NON-STEROIDAL LIGANDS FOR THE GLUCOCORTICOID RECEPTOR, COMPOSITIONS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2004-10-20 | — | — | EP | disclosed |
| US-20030176478-A1 | Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof | NIH-DEITR | 2003-09-18 | — | — | US | disclosed |
| WO-2003061651-A1 | NON-STEROIDAL LIGANDS FOR THE GLUCOCORTICOID RECEPTOR, COMPOSITIONS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2003-07-31 | — | — | WO | disclosed |