Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18772219 | 0.90 | DRD3 (0.32) | TLR8LMNA | |
| SCHEMBL18771991 | 0.89 | TLR8 (0.33) | TLR8 | |
| SCHEMBL18772064 | 0.84 | TLR8 (0.32) | TLR8 | |
| SCHEMBL18772155 | 0.83 | TLR8 (0.34) | TLR8 | |
| SCHEMBL19416589 | 0.83 | CYP4F2 (0.35) | — | |
| SCHEMBL18772202 | 0.82 | — | — | |
| SCHEMBL18772043 | 0.82 | TLR8 (0.42) | TLR8ALDH1A1 | |
| SCHEMBL19416343 | 0.82 | — | — | |
| SCHEMBL19416391 | 0.81 | — | — | |
| SCHEMBL18771679 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3159337-A2 | SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | Ventirx Pharmaceuticals, Inc. (US) | 2017-04-26 | — | — | EP | disclosed |