⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18381871 | 0.83 | GRIN2D (0.47) | — | |
| SCHEMBL25884400 | 0.83 | — | — | |
| SCHEMBL21256228 | 0.80 | LMNA (0.32) | — | |
| SCHEMBL18649749 | 0.80 | GRIN2D (0.34) | — | |
| SCHEMBL21256278 | 0.79 | — | — | |
| SCHEMBL14188080 | 0.79 | GRIN2D (0.43) | — | |
| SCHEMBL18912905 | 0.79 | CYP1A2 (0.33) | — | |
| SCHEMBL16470994 | 0.78 | GBA2 (0.32) | — | |
| SCHEMBL19003166 | 0.77 | — | — | |
| SCHEMBL18431954 | 0.76 | CYP1A2 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9632089-B2 | Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same | YALE UNIVERSITY (US) | 2017-04-25 | — | — | US | disclosed |