Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 20/20 | 0.64 |
| ▸ | DPP8 | Q6V1X1 | 9/20 | 0.52 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.50 |
| ▸ | ACE | P12821 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | FAP | Q12884 | 1/20 | 0.50 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1136099 | 0.87 | DPP4 (0.62) | DPP4DPP8DPP9ACEHTR2A | |
| SCHEMBL30406108 | 0.87 | DPP4 (0.62) | DPP4DPP8DPP9ACEHTR2A | |
| SCHEMBL1136100 | 0.87 | DPP4 (0.62) | DPP4DPP8DPP9ACEHTR2A | |
| SCHEMBL1136102 | 0.87 | DPP4 (0.62) | DPP4DPP8DPP9ACEHTR2A | |
| SCHEMBL25304263 | 0.82 | DPP4 (0.69) | DPP4DPP8DPP9ACEHTR2A | |
| SCHEMBL1409245 | 0.78 | DPP4 (1.00) | DPP4DPP8DPP9ACEHTR2A | |
| SCHEMBL17001389 | 0.77 | DPP4 (0.59) | DPP4DPP8DPP9ACEHTR2A | |
| SCHEMBL15166497 | 0.75 | DPP4 (0.57) | DPP4DPP8DPP9ACEHTR2A | |
| SCHEMBL16750213 | 0.74 | DPP4 (0.56) | DPP4DPP8DPP9ACEHTR2A | |
| SCHEMBL25842321 | 0.74 | DPP4 (0.76) | DPP4DPP8DPP9ACEHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11174266-B2 | Efficient process for the preparation of sitagliptin | F.I.S.—Fabbrica Italiana Sintetici S.p.A. (IT) | 2021-11-16 | — | — | US | disclosed |
| US-20210061808-A1 | NEW EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2021-03-04 | — | — | US | disclosed |
| US-10913747-B2 | Efficient process for the preparation of sitagliptin through a very effective preparation of the intermediate 2,4,5-trifluorophenylacetic acid | F.I.S.—Fabbrica Italiana Sintetici S.p.A. (IT) | 2021-02-09 | — | — | US | disclosed |
| US-20200157109-A1 | EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN THROUGH A VERY EFFECTIVE PREPARATION OF THE INTERMEDIATE 2,4,5-TRIFLUOROPHENYLACETIC ACID | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2020-05-21 | — | — | US | disclosed |
| WO-2019158285-A1 | NEW EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN. | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2019-08-22 | — | — | WO | disclosed |
| EP-3524605-A1 | NEW EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN | F.I.S.- Fabbrica Italiana Sintetici S.p.A. (IT) | 2019-08-14 | — | — | EP | disclosed |
| EP-3424927-B1 | EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN THROUGH A VERY EFFECTIVE PREPARATION OF THE INTERMEDIATE 2,4,5-TRIFLUOROPHENYLACETIC ACID | FIS FABBRICA ITALIANA SINTETICI SPA (IT) | 2019-04-17 | — | — | EP | disclosed |
| WO-2019007578-A1 | EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN THROUGH A VERY EFFECTIVE PREPARATION OF THE INTERMEDIATE 2,4,5-TRIFLUOROPHENYLACETIC ACID | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2019-01-10 | — | — | WO | disclosed |
| EP-3424927-A1 | EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN THROUGH A VERY EFFECTIVE PREPARATION OF THE INTERMEDIATE 2,4,5-TRIFLUOROPHENYLACETIC ACID | F.I.S.- Fabbrica Italiana Sintetici S.p.A. (IT) | 2019-01-09 | — | — | EP | disclosed |
| EP-3159343-B1 | IMPROVED PROCESS FOR THE PREPARATION OF TRIAZOLE AND SALT THEREOF | F I S - FABBRICA ITALIANA SINTETICI S P A (IT) | 2017-07-19 | — | — | EP | disclosed |
| EP-3159343-A1 | IMPROVED PROCESS FOR THE PREPARATION OF TRIAZOLE AND SALT THEREOF | F.I.S.- Fabbrica Italiana Sintetici S.p.A. (IT) | 2017-04-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210061808-A1 | NEW EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN | DPP4, DPP9, DPP7 | DPP4 1/4885DPP8 4/4885DPP9 2/4885 |
| US-11174266-B2 | Efficient process for the preparation of sitagliptin | DPP4, DPP9, DPP7 | DPP4 1/4885DPP8 5/4885DPP9 2/4885 |
| US-20200157109-A1 | EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN THROUGH A VERY EFFECTIVE PREPARATION OF THE INTERMEDIATE 2,4,5-TRIFLUOROPHENYLACETIC ACID | DPP4, DPP9, DPP7 | DPP4 1/4885DPP8 7/4885DPP9 2/4885 |
| US-10913747-B2 | Efficient process for the preparation of sitagliptin through a very effective preparation of the intermediate 2,4,5-trifluorophenylacetic acid | DPP4, DPP9, DPP7 | DPP4 1/4885DPP8 7/4885DPP9 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.