Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 20/20 | 0.69 |
| ▸ | DPP8 | Q6V1X1 | 11/20 | 0.56 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.54 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.54 |
| ▸ | ACE | P12821 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | FAP | Q12884 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25840245 | 0.91 | DPP4 (0.57) | DPP4DPP8DPP9DPP7ACE | |
| SCHEMBL29558815 | 0.87 | DPP4 (0.67) | DPP4DPP8DPP9DPP7ACE | |
| SCHEMBL214373 | 0.87 | DPP4 (0.67) | DPP4DPP8DPP9DPP7ACE | |
| SCHEMBL18774237 | 0.82 | DPP4 (0.64) | DPP4DPP8DPP9DPP7ACE | |
| SCHEMBL1409245 | 0.82 | DPP4 (1.00) | DPP4DPP8DPP9DPP7ACE | |
| SCHEMBL25842321 | 0.81 | DPP4 (0.76) | DPP4DPP8DPP9DPP7ACE | |
| SCHEMBL16993649 | 0.79 | DPP4 (0.56) | DPP4DPP8DPP9DPP7ACE | |
| SCHEMBL8223780 | 0.79 | DPP4 (0.53) | DPP4DPP8DPP9DPP7ACE | |
| Sitagliptin SCHEMBL3513247 | 0.78 | DPP4 (0.86) | DPP4DPP8DPP9DPP7ACE | |
| SCHEMBL8223854 | 0.77 | DPP4 (0.59) | DPP4DPP8DPP9DPP7ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230227457-A1 | IMPROVED PROCESS FOR PREPARATION OF SITAGLIPTIN | AARTI PHARMALABS LIMITED (IN) | 2023-07-20 | — | — | US | disclosed |
| US-20230227457-A1 | IMPROVED PROCESS FOR PREPARATION OF SITAGLIPTIN | AARTI PHARMALABS LIMITED (IN) | 2023-07-20 | — | — | US | disclosed |
| US-20230227457-A1 | IMPROVED PROCESS FOR PREPARATION OF SITAGLIPTIN | AARTI PHARMALABS LIMITED (IN) | 2023-07-20 | — | — | US | disclosed |
| EP-4164620-A1 | IMPROVED PROCESS FOR PREPARATION OF SITAGLIPTIN | Aarti Industries Limited (IN) | 2023-04-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230227457-A1 | IMPROVED PROCESS FOR PREPARATION OF SITAGLIPTIN | DPP4, DPP9, DPP8 | DPP4 1/4885DPP8 3/4885DPP9 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.