Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 9/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.40 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14927193 | 1.00 | BTK (0.43) | BTKHDAC1GPR119MAP4K4SUV39H2 | |
| SCHEMBL14924373 | 1.00 | BTK (0.43) | BTKHDAC1GPR119MAP4K4SUV39H2 | |
| SCHEMBL14924364 | 0.88 | BTK (0.41) | BTKGPR119 | |
| SCHEMBL14915354 | 0.88 | BTK (0.42) | BTKWNT3A | |
| SCHEMBL10256044 | 0.87 | WNT3A (0.48) | BTKGPR119WNT3A | |
| SCHEMBL30507867 | 0.85 | BTK (0.54) | BTKGPR119SETD7 | |
| SCHEMBL10256545 | 0.85 | BTK (0.44) | BTKHDAC1GPR119WNT3A | |
| SCHEMBL25524769 | 0.85 | BTK (0.54) | BTKGPR119SETD7 | |
| SCHEMBL14912698 | 0.84 | BTK (0.45) | BTKGPR119 | |
| SCHEMBL14915914 | 0.84 | BTK (0.45) | BTKGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022133184-A1 | BTK DEGRADER | NEWAVE PHARMACEUTICAL INC. (US) | 2022-06-23 | — | — | WO | disclosed |
| EP-3002284-B1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS AS INHIBITORS OF BTK ACTIVITY | HOFFMANN LA ROCHE (CH) | 2019-05-22 | — | — | EP | disclosed |
| EP-2773639-B1 | ALKYLATED PIPERAZINE COMPOUNDS AS INHIBITORS OF BTK ACTIVITY | HOFFMANN LA ROCHE (CH) | 2017-04-26 | — | — | EP | disclosed |