⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17253332 | 0.85 | HCAR2 (0.37) | — | |
| SCHEMBL20832527 | 0.79 | — | — | |
| SCHEMBL20927761 | 0.77 | — | — | |
| SCHEMBL13075767 | 0.77 | — | — | |
| SCHEMBL23609236 | 0.77 | — | — | |
| SCHEMBL19661047 | 0.74 | — | — | |
| SCHEMBL21339352 | 0.74 | — | — | |
| SCHEMBL12948850 | 0.74 | — | — | |
| SCHEMBL24318062 | 0.74 | — | — | |
| SCHEMBL16449156 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11524960-B2 | Heterobicyclic inhibitors of MAT2A and methods of use for treating cancer | SERVIER PHARMACEUTICALS LLC (US) | 2022-12-13 | — | — | US | disclosed |
| EP-3326715-B1 | OXALIC ACID MONOAMIDE LIGAND, AND USES THEREOF IN COUPLING REACTION OF COPPER-CATALYZED ARYL HALOGEN SUBSTITUTE | CE PHARM CO LTD (CN) | 2021-09-15 | — | — | EP | disclosed |
| US-20210115045-A1 | HETEROBICYCLIC INHIBITORS OF MAT2A AND METHODS OF USE FOR TREATING CANCER | SERVIER PHARMACEUTICALS LLC | 2021-04-22 | — | — | US | disclosed |
| WO-2020140054-A1 | CYCLIN-DEPENDENT KINASE INHIBITORS | SPV THERAPEUTICS INC. (US) | 2020-07-02 | — | — | WO | disclosed |
| US-20200148716-A1 | AZIRIDINE SPINOSYN DERIVATIVES AND METHODS OF MAKING | AGRIMETIS, LLC (US) | 2020-05-14 | — | — | US | disclosed |
| US-10570165-B2 | Aziridine spinosyn derivatives and methods of making | AGRIMETIS, LLC (US) | 2020-02-25 | — | — | US | disclosed |
| US-10022461-B2 | Pyrrolo[2,3-C]pyridines as imaging agents for neurofibrilary tangles | MERCK SHARP & DOHME CORP. (US) | 2018-07-17 | — | — | US | disclosed |
| US-20180071412-A1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES | MERCK SHARP & DOHME CORP. (US) | 2018-03-15 | — | — | US | disclosed |
| US-9808542-B2 | Pyrrolo[2,3-C]pyridines as imaging agents for neurofibrillary | MERCK SHARP & DOHME CORP. (US) | 2017-11-07 | — | — | US | disclosed |
| US-9676782-B2 | Substituted pyrazolo[1,5-a]pyrazines as negative allosteric modulators of metabotropic glutamate receptor 3 | VANDERBILT UNIVERSITY (US) | 2017-06-13 | — | — | US | disclosed |
| US-20170119912-A1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILLARY | MERCK SHARP & DOHME CORP. (US) | 2017-05-04 | — | — | US | disclosed |
| US-9630970-B2 | TYK2 inhibitors and uses thereof | NIMBUS LAKSHMI, INC. (US) | 2017-04-25 | — | — | US | disclosed |