⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL8856781 | 0.83 | HPGD (0.50) | — | |
| SCHEMBL28078669 | 0.82 | HDAC1 (0.72) | — | |
| SCHEMBL12181209 | 0.80 | — | — | |
| SCHEMBL5160725 | 0.79 | CES2 (0.54) | — | |
| SCHEMBL18912328 | 0.79 | HDAC1 (0.56) | — | |
| SCHEMBL15296676 | 0.79 | HDAC1 (0.56) | — | |
| SCHEMBL3415908 | 0.78 | — | — | |
| SCHEMBL6957032 | 0.78 | — | — | |
| SCHEMBL7223253 | 0.78 | HDAC1 (0.60) | — | |
| SCHEMBL8627533 | 0.78 | HDAC1 (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-8099973-A | — | — | None | — | — | JP | disclosed |
| EP-4168399-B1 | COMPOUNDS AND THEIR USES AS MIF INHIBITORS | NANJING IMMUNOPHAGE BIOMEDICAL CO LTD (CN) | 2026-04-01 | — | — | EP | disclosed |
| CN-114989155-B | 1,3, 4-oxadiazole thioether derivative, and preparation method and application thereof | 河北农业大学 | 2024-04-02 | — | — | CN | disclosed |
| US-20240083912-A1 | COMPOUNDS AND THEIR USES AS MIF INHIBITORS | NANJING IMMUNOPHAGE BIOTECH CO LTD (CN) | 2024-03-14 | — | — | US | disclosed |
| US-11884682-B2 | Compounds and their uses as MIF inhibitors | Nanjing Immunophage Biotech Co., Ltd. (CN) | 2024-01-30 | — | — | US | disclosed |
| CN-116438174-A | Compounds and their use as MIF inhibitors | 南京艾美斐生物医药科技有限公司 | 2023-07-14 | — | — | CN | disclosed |
| EP-4168399-A1 | COMPOUNDS AND THEIR USES AS MIF INHIBITORS | Nanjing Immunophage Biotech Co., Ltd. (CN) | 2023-04-26 | — | — | EP | disclosed |
| US-20230113037-A1 | [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINES | BAYER AKTIENGESELLSCHAFT (DE) | 2023-04-13 | — | — | US | disclosed |
| US-20230113037-A1 | [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINES | BAYER AKTIENGESELLSCHAFT (DE) | 2023-04-13 | — | — | US | disclosed |
| CN-114989155-A | 1,3, 4-oxadiazole thioether derivative and preparation method and application thereof | 河北农业大学 | 2022-09-02 | — | — | CN | disclosed |
| US-20030060467-A1 | Pyrazolo-triazine derivatives as ligands for gaba receptors | MERCK SHARP & DOHME LTD. (GB) | 2003-03-27 | — | — | US | disclosed |
| EP-1282623-A1 | PYRAZOLO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2003-02-12 | — | — | EP | disclosed |
| WO-2001077111-A1 | PYRAZOLO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2001-10-18 | — | — | WO | disclosed |
| US-20010026915-A1 | Colorimetric glycopolythiophene biosensors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2001-10-04 | — | — | US | disclosed |
| US-6265426-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-07-24 | — | — | US | disclosed |
| EP-1070708-A1 | Triazole and imidazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2001-01-24 | — | — | EP | disclosed |
| JP-H0899973-A | THIOPHENE MONOMER HAVING DIACYLHYDRAZIDE GROUP ON SIDE CHAIN | MITSUBISHI PAPER MILLS LTD | 1996-04-16 | — | — | JP | disclosed |
| EP-0566446-A1 | Derivatives of indane-1,3-dione and indane-1,2,3-trione, processes for their preparation and their application in therapy | INNOTHERA (FR) | 1993-10-20 | — | — | EP | disclosed |
| WO-1993020046-A1 | INDAN-1,3-DIONE AND INDAN-1,2,3-TRIONE DERIVATIVES, PROCESSES FOR PREPARATION OF SAME AND THEIR USE AS THERAPEUTIC AGENTS | INNOTHERA (FR) | 1993-10-14 | — | — | WO | disclosed |
| US-4111956-A | Process for the manufacture of heterocyclic compounds | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1978-09-05 | — | — | US | disclosed |