Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | NQO1 | P15559 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2153419 | 0.84 | TP53 (0.61) | MAPTALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL816372 | 0.84 | MAPT (0.52) | MAPTALDH1A1TP53CYP3A4LMNA | |
| SCHEMBL16959259 | 0.83 | L3MBTL1 (0.44) | MAPTALDH1A1L3MBTL1LMNAFGFR2 | |
| SCHEMBL21432531 | 0.83 | L3MBTL1 (0.44) | TSHRL3MBTL1LMNAFGFR2FGFR3 | |
| SCHEMBL24051492 | 0.82 | L3MBTL1 (0.41) | MAPTALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL16959256 | 0.81 | L3MBTL1 (0.43) | MAPTALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL16770632 | 0.81 | L3MBTL1 (0.43) | MAPTTSHRTDP1L3MBTL1LMNA | |
| SCHEMBL19433327 | 0.80 | MAPT (0.36) | MAPTALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL7043105 | 0.80 | TP53 (0.61) | MAPTALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL27213513 | 0.80 | MAPT (0.46) | MAPTALDH1A1TP53CYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017070708-A1 | 2-ARYL- AND 2-HETEROARYL-SUBSTITUTED 2-PYRIDAZIN-3(2H)-ONE COMPOUNDS AS INHIBITORS OF FGFR TYROSINE KINASES | ARRAY BIOPHARMA, INC. (US) | 2017-04-27 | — | — | WO | disclosed |