Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.49 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 9/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28307753 | 0.79 | MEN1 (0.58) | MAPKAPK2RPS6KA3CSNK2A1PLK3MEN1 | |
| SCHEMBL118057 | 0.79 | MEN1 (0.57) | MAPKAPK2RPS6KA3CSNK2A1PLK3MEN1 | |
| SCHEMBL29449363 | 0.79 | MEN1 (0.57) | MAPKAPK2RPS6KA3CSNK2A1PLK3MEN1 | |
| Hydrochloric Acid SCHEMBL6621838 | 0.78 | MEN1 (0.55) | MAPKAPK2RPS6KA3CSNK2A1PLK3MEN1 | |
| SCHEMBL19364711 | 0.77 | RAD52 (0.43) | F2LMNAHTR1AADRA2ADRD1 | |
| SCHEMBL1663309 | 0.76 | MAPKAPK2 (0.49) | MAPKAPK2RPS6KA3CSNK2A1PLK3MEN1 | |
| SCHEMBL1925825 | 0.76 | KDM4E (0.57) | MAPKAPK2RPS6KA3CSNK2A1PLK3MEN1 | |
| SCHEMBL1143305 | 0.76 | MAPKAPK2 (0.49) | MAPKAPK2RPS6KA3CSNK2A1PLK3MEN1 | |
| SCHEMBL3035648 | 0.76 | MAPKAPK2 (0.49) | MAPKAPK2RPS6KA3CSNK2A1PLK3MEN1 | |
| SCHEMBL25606670 | 0.76 | MAPKAPK2 (0.49) | MAPKAPK2RPS6KA3CSNK2A1PLK3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10752611-B2 | Benzimidazole derivatives | ENANTA PHARMACEUTICALS, INC. (US) | 2020-08-25 | — | — | US | disclosed |
| US-10017499-B2 | Benzimidazole derivatives | ENANTA PHARMACEUTICALS, INC. (US) | 2018-07-10 | — | — | US | disclosed |
| US-9765087-B2 | Benzimidazole derivatives | ENANTA PHARMACEUTICALS, INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-20170114046-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | ENANTA PHARM INC (US) | 2017-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170114046-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | EIF2AK2, ZC3HAV1, HAVCR2 | MAPKAPK2 4053/4885RPS6KA3 2662/4885CSNK2A1 791/4885 |
| US-10017499-B2 | Benzimidazole derivatives | EIF2AK2, ZC3HAV1, ZC3HAV1L | MAPKAPK2 4367/4885RPS6KA3 3264/4885CSNK2A1 1208/4885 |
| US-10752611-B2 | Benzimidazole derivatives | EIF2AK2, ZC3HAV1, ZC3HAV1L | MAPKAPK2 4367/4885RPS6KA3 3264/4885CSNK2A1 1208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.