SCHEMBL1663309

SCHEMBL1663309

Nc1ccc2[nH]c(Cl)nc2c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPKAPK2 P49137 1/20 0.49
RPS6KA3 P51812 1/20 0.49
CSNK2A1 P68400 1/20 0.49
PLK3 Q9H4B4 1/20 0.49
MEN1 O00255 11/20 0.44
KMT2A Q03164 11/20 0.44
MAPT P10636 10/20 0.44
GAA P10253 8/20 0.44
KDM4E B2RXH2 8/20 0.44
ALDH1A1 P00352 7/20 0.44
RAB9A P51151 7/20 0.44
HPGD P15428 6/20 0.44
SMN1; SMN2 Q16637 6/20 0.44
NPC1 O15118 6/20 0.44
POLB P06746 5/20 0.44
TDP1 Q9NUW8 4/20 0.44
TP53 P04637 3/20 0.44
USP2 O75604 3/20 0.44
LMNA P02545 2/20 0.44
CACNA1B Q00975 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1663312 0.84 MAPT (0.60) MEN1KMT2AMAPTGAAKDM4E
SCHEMBL118057 0.79 MEN1 (0.57) MAPKAPK2RPS6KA3CSNK2A1PLK3MEN1
SCHEMBL29449363 0.79 MEN1 (0.57) MAPKAPK2RPS6KA3CSNK2A1PLK3MEN1
SCHEMBL28307753 0.79 MEN1 (0.58) MAPKAPK2RPS6KA3CSNK2A1PLK3MEN1
SCHEMBL1192946 0.79 F7 (0.47) MEN1KMT2AMAPTKDM4EALDH1A1
Hydrochloric Acid SCHEMBL6621838 0.78 MEN1 (0.55) MAPKAPK2RPS6KA3CSNK2A1PLK3MEN1
SCHEMBL18782889 0.76 MAPKAPK2 (0.49) MAPKAPK2RPS6KA3CSNK2A1PLK3MEN1
SCHEMBL3035648 0.76 MAPKAPK2 (0.49) MAPKAPK2RPS6KA3CSNK2A1PLK3MEN1
SCHEMBL1925825 0.76 KDM4E (0.57) MAPKAPK2RPS6KA3CSNK2A1PLK3MEN1
SCHEMBL1143305 0.76 MAPKAPK2 (0.49) MAPKAPK2RPS6KA3CSNK2A1PLK3MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4733300-A1 NOVEL CHROMENE-BENZIMIDAZOLE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND USE THEREOF Korea University Research and Business Foundation (KR) 2026-04-29 EP disclosed
US-12552770-B2 Compounds for treating respiratory disease TMEM16A LIMITED (GB) 2026-02-17 US disclosed
WO-2024263007-A1 NOVEL CHROMENE-BENZIMIDAZOLE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND USE THEREOF 고려대학교 산학협력단 2024-12-26 WO disclosed
CN-114269721-B Compounds for the treatment of respiratory diseases TMEM16A有限公司 2024-12-20 CN disclosed
US-20240066023-A1 Method for producing benzazoloquinolium (BQs) salts and using the biological activity of the composition SISTEMA UNIVERSITARIO ANA G. MENDEZ, INC. (US) 2024-02-29 US disclosed
US-11786520-B2 Method for producing benzazoloquinolium (BQs) salts and using the biological activity of the composition SISTEMA UNIV ANA G MENDEZ INC (US) 2023-10-17 US disclosed
US-11311531-B2 Method for producing benzazoloquinolium (BQs) salts and using the biological activity of the composition SISTEMA UNIV ANA G MENDEZ INC (US) 2022-04-26 US disclosed
EP-3983389-A1 COMPOUNDS FOR TREATING RESPIRATORY DISEASE TMEM16A LIMITED (GB) 2022-04-20 EP disclosed
CN-114269721-A Compounds for the treatment of respiratory diseases TMEM16A有限公司 2022-04-01 CN disclosed
US-20220098167-A1 COMPOUNDS FOR TREATING RESPIRATORY DISEASE TMEM16A LTD (GB) 2022-03-31 US disclosed
CN-103282034-A Use of hematopoietic growth factor mimetics LIGAND PHARM INC 2013-09-04 CN disclosed
US-20120295904-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES LIGAND PHARMACEUTICALS INC. (US) 2012-11-22 US disclosed
EP-2488486-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES Ligand Pharmaceuticals Inc. (US) 2012-08-22 EP disclosed
WO-2012068406-A2 USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS LIGAND PHARMACEUTICALS INCORPORATED (US) 2012-05-24 WO disclosed
WO-2011046954-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES LIGAND PHARMACEUTICALS INC. (US) 2011-04-21 WO disclosed
WO-2010036544-A1 OXAZOLOBENZIMIDAZOLE DERIVATIVES MERCK SHARP & DOHME CORP. (US) 2010-04-01 WO disclosed
WO-2004092181-A9 HETEROCYCLIC MCHR1 ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2005-01-27 WO disclosed
US-5347008-A Thio(cyclo) alkanepolycarboxylic acids containing heterocyclic substituents CIBA-GEIGY CORPORATION (US) 1994-09-13 US disclosed
US-5152929-A Corrosion inhibitors for water systems CIBA-GEIGY CORPORATION (US) 1992-10-06 US disclosed
EP-0129506-A2 Heterocyclically substituted thio(cyclo)alkane polycarboxylic acids CIBA-GEIGY AG (CH) 1984-12-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11786520-B2 Method for producing benzazoloquinolium (BQs) salts and using the biological activity of the composition AHNAK, RECQL, NBAS MAPKAPK2 3411/4885RPS6KA3 3594/4885CSNK2A1 2581/4885
US-12552770-B2 Compounds for treating respiratory disease TMEM109, SCN1A, SLC16A1 MAPKAPK2 2372/4885RPS6KA3 2863/4885CSNK2A1 1731/4885
US-11311531-B2 Method for producing benzazoloquinolium (BQs) salts and using the biological activity of the composition RECQL, AHNAK, NDUFS1 MAPKAPK2 3466/4885RPS6KA3 3613/4885CSNK2A1 2398/4885
US-20120295904-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES MPL, CSF3R, HGF MAPKAPK2 2051/4885RPS6KA3 2169/4885CSNK2A1 3249/4885
US-20240066023-A1 Method for producing benzazoloquinolium (BQs) salts and using the biological activity of the composition AHNAK, RECQL, NBAS MAPKAPK2 3411/4885RPS6KA3 3594/4885CSNK2A1 2581/4885
US-20220098167-A1 COMPOUNDS FOR TREATING RESPIRATORY DISEASE TMEM109, SLC16A1, CFTR MAPKAPK2 4643/4885RPS6KA3 2653/4885CSNK2A1 2816/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.