Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18807748 | 0.98 | ERAP1 (0.36) | PTPN1ERAP1KIF11KDM4EMEN1 | |
| Fluoride Ion SCHEMBL18784476 | 0.97 | ERAP1 (0.35) | PTPN1ERAP1KIF11KDM4EMEN1 | |
| Bromide SCHEMBL19095359 | 0.97 | ERAP1 (0.35) | PTPN1ERAP1KIF11KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL18784500 | 0.97 | ERAP1 (0.38) | PTPN1ERAP1KIF11KDM4EMEN1 | |
| SCHEMBL18784535 | 0.94 | ERAP1 (0.33) | PTPN1ERAP1KIF11KDM4EMEN1 | |
| SCHEMBL18784617 | 0.89 | LMNA (0.38) | ERAP1KDM4EMEN1KMT2ARAB9A | |
| Trifluoromethanesulfonic Acid SCHEMBL18784543 | 0.87 | LMNA (0.38) | KDM4EMEN1KMT2ARAB9APOLB | |
| SCHEMBL18784434 | 0.85 | LMNA (0.49) | KDM4EMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL18784459 | 0.84 | LMNA (0.40) | ERAP1KDM4EMEN1KMT2ARAB9A | |
| Iodide SCHEMBL18784417 | 0.83 | APOBEC3A (0.46) | ERAP1KIF11KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3162799-B1 | FLUOROALKYLATING AGENT | KUMIAI CHEMICAL INDUSTRY CO (JP) | 2021-03-10 | — | — | EP | disclosed |
| US-10696640-B2 | Fluoroalkylating agent | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 2020-06-30 | — | — | US | disclosed |
| US-20190233380-A1 | FLUOROALKYLATING AGENT | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 2019-08-01 | — | — | US | disclosed |
| US-10308613-B2 | Fluoroalkylating agent | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 2019-06-04 | — | — | US | disclosed |
| US-20170197920-A1 | FLUOROALKYLATING AGENT | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2017-07-13 | — | — | US | disclosed |
| EP-3162799-A1 | FLUOROALKYLATING AGENT | Ihara Chemical Industry Co., Ltd. (JP) | 2017-05-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10308613-B2 | Fluoroalkylating agent | AFF1, AFF4, AFF2 | PTPN1 2066/4885ERAP1 3567/4885KIF11 445/4885 |
| US-10696640-B2 | Fluoroalkylating agent | AFF1, AFF4, AFF2 | PTPN1 2066/4885ERAP1 3567/4885KIF11 445/4885 |
| US-20190233380-A1 | FLUOROALKYLATING AGENT | AFF1, AFF4, AFF2 | PTPN1 2066/4885ERAP1 3567/4885KIF11 445/4885 |
| US-20170197920-A1 | FLUOROALKYLATING AGENT | AFF1, AFF4, AFF2 | PTPN1 2066/4885ERAP1 3567/4885KIF11 445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.