Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.44 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL18787174 | 1.00 | KDM4E (0.54) | KDM4EALDH1A1TDP1PSMB8PSMB5 | |
| SCHEMBL16899126 | 0.92 | KDM4E (0.58) | KDM4EALDH1A1TDP1PSMB8PSMB5 | |
| SCHEMBL16899279 | 0.92 | KDM4E (0.58) | KDM4EALDH1A1TDP1PSMB8PSMB5 | |
| Trifluoroacetic Acid SCHEMBL18787200 | 0.92 | KDM4E (0.51) | KDM4EALDH1A1TDP1PSMB8PSMB5 | |
| Trifluoroacetic Acid SCHEMBL18787201 | 0.92 | KDM4E (0.51) | KDM4EALDH1A1TDP1PSMB8PSMB5 | |
| Trifluoroacetic Acid SCHEMBL16899193 | 0.86 | PSMB8 (0.53) | KDM4EALDH1A1TDP1PSMB8PSMB5 | |
| Trifluoroacetic Acid SCHEMBL16899197 | 0.86 | PSMB8 (0.53) | KDM4EALDH1A1TDP1PSMB8PSMB5 | |
| Trifluoroacetic Acid SCHEMBL18787154 | 0.85 | CARM1 (0.52) | KDM4EALDH1A1TDP1PSMB5MEN1 | |
| Trifluoroacetic Acid SCHEMBL18787156 | 0.85 | CARM1 (0.52) | KDM4EALDH1A1TDP1PSMB5MEN1 | |
| SCHEMBL16908241 | 0.83 | KDM4E (0.55) | KDM4EALDH1A1TDP1PSMB8PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE49816-E1 | Dipeptides as inhibitors of human immunoproteasomes | CORNELL UNIVERSITY (US) | 2024-01-30 | — | — | US | disclosed |
| EP-3092244-B1 | DIPEPTIDES AS INHIBITORS OF HUMAN IMMUNOPROTEASOMES | UNIV CORNELL (US) | 2019-08-14 | — | — | EP | disclosed |
| US-9988421-B2 | Dipeptides as inhibitors of human immunoproteasomes | CORNELL UNIVERSITY (US) | 2018-06-05 | — | — | US | disclosed |
| US-20170121366-A1 | DIPEPTIDES AS INHIBITORS OF HUMAN IMMUNOPROTEASOMES | CORNELL UNIVERSITY | 2017-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170121366-A1 | DIPEPTIDES AS INHIBITORS OF HUMAN IMMUNOPROTEASOMES | DNPEP, PSMB10, DPEP1 | KDM4E 809/4885ALDH1A1 3918/4885TDP1 522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.