Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9962424 | 0.86 | MAPT (0.43) | MAPTMEN1ALDH1A1KMT2AEPHX1 | |
| SCHEMBL30242034 | 0.86 | MAPT (0.43) | MAPTMEN1ALDH1A1KMT2AEPHX1 | |
| SCHEMBL16786560 | 0.83 | MAPT (0.41) | MAPTMEN1ALDH1A1KMT2AEPHX1 | |
| SCHEMBL18790624 | 0.83 | HPGD (0.42) | MAPTMEN1ALDH1A1KMT2AEPHX1 | |
| SCHEMBL16691765 | 0.82 | SCN9A (0.35) | MAPTMEN1ALDH1A1KMT2AEPHX1 | |
| SCHEMBL16789933 | 0.80 | ALDH1A1 (0.39) | MAPTMEN1ALDH1A1KMT2AEPHX1 | |
| SCHEMBL22240440 | 0.79 | MAPT (0.37) | MAPTMEN1ALDH1A1KMT2AEPHX1 | |
| SCHEMBL30242026 | 0.70 | HPGD (0.45) | MAPTMEN1ALDH1A1KMT2AEPHX1 | |
| SCHEMBL9962386 | 0.70 | HPGD (0.45) | MAPTMEN1ALDH1A1KMT2AEPHX1 | |
| SCHEMBL28169096 | 0.70 | HPGD (0.45) | MAPTMEN1ALDH1A1KMT2AEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170114039-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BIOGEN IDEC MA INC. | 2017-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170114039-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | ABL1, BTK, LYN | MAPT 4175/4885MEN1 3327/4885ALDH1A1 4528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.