Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 1/20 | 0.36 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.36 |
| ▸ | FEN1 | P39748 | 2/20 | 0.36 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.36 |
| ▸ | DNASE1 | P24855 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PRKDC | P78527 | 2/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | EEF2K | O00418 | 1/20 | 0.33 |
| ▸ | BUB1 | O43683 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17347876 | 1.00 | CALCRL (0.36) | CALCRLERCC1FEN1ERCC4DNASE1 | |
| SCHEMBL18763278 | 1.00 | CALCRL (0.36) | CALCRLERCC1FEN1ERCC4DNASE1 | |
| SCHEMBL18792951 | 1.00 | CALCRL (0.36) | CALCRLERCC1FEN1ERCC4DNASE1 | |
| SCHEMBL18763311 | 0.86 | OPRM1 (0.37) | ERCC1FEN1ERCC4DNASE1PIK3CA | |
| SCHEMBL18792947 | 0.86 | OPRM1 (0.37) | ERCC1FEN1ERCC4DNASE1PIK3CA | |
| SCHEMBL18763312 | 0.86 | OPRM1 (0.37) | ERCC1FEN1ERCC4DNASE1PIK3CA | |
| SCHEMBL18792924 | 0.86 | OPRM1 (0.37) | ERCC1FEN1ERCC4DNASE1PIK3CA | |
| SCHEMBL17347952 | 0.85 | ERCC1 (0.36) | ERCC1FEN1ERCC4DNASE1PIK3CA | |
| SCHEMBL17347877 | 0.85 | ERCC1 (0.36) | ERCC1FEN1ERCC4DNASE1PIK3CA | |
| SCHEMBL18792922 | 0.85 | ERCC1 (0.36) | ERCC1FEN1ERCC4DNASE1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170114029-A1 | TREATMENT OF CHAGAS DISEASE | SYNGENE INTERNATIONAL LIMITED (IN) | 2017-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170114029-A1 | TREATMENT OF CHAGAS DISEASE | CXCR4, CBR1, CHRM1 | CALCRL 1244/4885ERCC1 2255/4885FEN1 4772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.