Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.63 |
| ▸ | FLT3 | P36888 | 20/20 | 0.63 |
| ▸ | TYK2 | P29597 | 14/20 | 0.63 |
| ▸ | CDK2 | P24941 | 14/20 | 0.63 |
| ▸ | CCNA2 | P20248 | 13/20 | 0.63 |
| ▸ | CCNA1 | P78396 | 13/20 | 0.63 |
| ▸ | JAK1 | P23458 | 10/20 | 0.63 |
| ▸ | JAK3 | P52333 | 3/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | CCNK | O75909 | 1/20 | 0.54 |
| ▸ | STK10 | O94804 | 1/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | PRKCB | P05771 | 1/20 | 0.54 |
| ▸ | CDK1 | P06493 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21784434 | 0.96 | JAK2 (0.70) | JAK2FLT3TYK2CDK2CCNA2 | |
| SCHEMBL1108223 | 0.86 | JAK2 (0.78) | JAK2FLT3TYK2CDK2CCNA2 | |
| SCHEMBL21784408 | 0.85 | JAK2 (0.74) | JAK2FLT3TYK2CDK2CCNA2 | |
| SCHEMBL1108225 | 0.83 | JAK2 (0.71) | JAK2FLT3TYK2CDK2CCNA2 | |
| SCHEMBL1108219 | 0.83 | JAK2 (0.71) | JAK2FLT3TYK2CDK2CCNA2 | |
| SCHEMBL23079067 | 0.80 | JAK2 (0.69) | JAK2FLT3TYK2CDK2CCNA2 | |
| SCHEMBL11955406 | 0.79 | JAK2 (1.00) | JAK2FLT3TYK2CDK2CCNA2 | |
| SCHEMBL1108230 | 0.79 | JAK2 (1.00) | JAK2FLT3TYK2CDK2CCNA2 | |
| SCHEMBL1108228 | 0.79 | JAK2 (1.00) | JAK2FLT3TYK2CDK2CCNA2 | |
| SCHEMBL23079068 | 0.79 | JAK2 (0.64) | JAK2FLT3TYK2CDK2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170112846-A1 | OXYGEN LINKED PYRIMIDINE DERIVATIVES | CTI BIOPHARMA CORP. (US) | 2017-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170112846-A1 | OXYGEN LINKED PYRIMIDINE DERIVATIVES | DPYD, TK2, TK1 | JAK2 468/4885FLT3 645/4885TYK2 960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.