Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Ethylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene Glycol SCHEMBL332774 | 1.00 | TSHR (0.46) | TSHRALDH1A1SMN1; SMN2LMNAHSD17B10 | |
| Ethylene Glycol SCHEMBL8333223 | 1.00 | TSHR (0.46) | TSHRALDH1A1SMN1; SMN2LMNAHSD17B10 | |
| Ethylene Glycol SCHEMBL1115046 | 0.96 | TSHR (0.43) | TSHRALDH1A1SMN1; SMN2 | |
| Ethylene Glycol SCHEMBL3171689 | 0.92 | TSHR (0.46) | TSHRALDH1A1 | |
| Ethylene Glycol SCHEMBL622577 | 0.92 | TSHR (0.46) | TSHRALDH1A1 | |
| Ethylene Glycol SCHEMBL4769225 | 0.92 | TSHR (0.46) | TSHRALDH1A1 | |
| Ethylene Glycol SCHEMBL9756248 | 0.92 | TSHR (0.46) | TSHRALDH1A1 | |
| Ethylene Glycol SCHEMBL5830392 | 0.92 | TSHR (0.46) | TSHRALDH1A1 | |
| Ethylene Glycol SCHEMBL3200076 | 0.92 | TSHR (0.46) | TSHRALDH1A1 | |
| Ethylene Glycol SCHEMBL3197361 | 0.92 | TSHR (0.46) | TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110112121-A1 | Pharmaceutical Compositions and Solid Forms | NOVARTIS AG (CH) | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112121-A1 | Pharmaceutical Compositions and Solid Forms | VEGFA, FLT1, FLT4 | TSHR 4199/4885ALDH1A1 550/4885SMN1; SMN2 477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.