Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 8/20 | 0.74 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17480161 | 0.97 | PDE3B (0.80) | PDE3BPDE3AALDH1A1MEN1KMT2A | |
| SCHEMBL18796668 | 0.90 | PDE3B (0.77) | PDE3BPDE3AALDH1A1TP53MAPT | |
| SCHEMBL18796771 | 0.90 | PDE3B (0.77) | PDE3BPDE3AALDH1A1 | |
| SCHEMBL18796783 | 0.90 | PDE3B (0.77) | PDE3BPDE3AALDH1A1MEN1KMT2A | |
| SCHEMBL18796702 | 0.89 | PDE3B (0.94) | PDE3BPDE3AALDH1A1GAATP53 | |
| SCHEMBL18819702 | 0.89 | PDE3B (0.69) | PDE3BPDE3AALDH1A1MEN1KMT2A | |
| SCHEMBL18796759 | 0.88 | PDE3B (0.77) | PDE3BPDE3AALDH1A1KMT2A | |
| SCHEMBL18796674 | 0.88 | PDE3B (0.77) | PDE3BPDE3AALDH1A1MEN1KMT2A | |
| SCHEMBL18796791 | 0.88 | PDE3B (0.63) | PDE3BPDE3AALDH1A1GAAMAPT | |
| SCHEMBL18796708 | 0.88 | PDE3B (0.80) | PDE3BPDE3AALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017072796-A1 | 2-PYRIDONE BASED COMPOUNDS USEFUL AS POTENTIAL PHOSPHODIESTERASE3A (PDE3A)INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-05-04 | — | — | WO | claimed |
| WO-2017072796-A1 | 2-PYRIDONE BASED COMPOUNDS USEFUL AS POTENTIAL PHOSPHODIESTERASE3A (PDE3A)INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-05-04 | — | — | WO | disclosed |
| WO-2017072796-A1 | 2-PYRIDONE BASED COMPOUNDS USEFUL AS POTENTIAL PHOSPHODIESTERASE3A (PDE3A)INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-05-04 | — | — | WO | disclosed |