Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 6/20 | 0.69 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18796628 | 0.89 | PDE3B (0.74) | PDE3BPDE3AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL18796695 | 0.86 | PDE3B (0.76) | PDE3BPDE3AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL18796633 | 0.85 | PDE3B (0.62) | PDE3BPDE3AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL18796699 | 0.85 | PDE3B (0.54) | PDE3BPDE3AALDH1A1POLBGAA | |
| SCHEMBL18796736 | 0.81 | PDE3B (0.77) | PDE3BPDE3AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL18820635 | 0.79 | PDE3B (0.81) | PDE3BPDE3AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL18796638 | 0.78 | PDE3B (0.79) | PDE3BPDE3AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL18796691 | 0.77 | PDE3B (0.70) | PDE3BPDE3AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL18796715 | 0.77 | PDE3B (0.78) | PDE3BPDE3AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL18796658 | 0.76 | PDE3B (0.76) | PDE3BPDE3AALDH1A1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017072796-A1 | 2-PYRIDONE BASED COMPOUNDS USEFUL AS POTENTIAL PHOSPHODIESTERASE3A (PDE3A)INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-05-04 | — | — | WO | claimed |
| WO-2017072796-A1 | 2-PYRIDONE BASED COMPOUNDS USEFUL AS POTENTIAL PHOSPHODIESTERASE3A (PDE3A)INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-05-04 | — | — | WO | disclosed |
| WO-2017072796-A1 | 2-PYRIDONE BASED COMPOUNDS USEFUL AS POTENTIAL PHOSPHODIESTERASE3A (PDE3A)INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-05-04 | — | — | WO | disclosed |