Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 8/20 | 0.80 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18796783 | 0.98 | PDE3B (0.77) | PDE3BPDE3AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL18819702 | 0.90 | PDE3B (0.69) | PDE3BPDE3AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL16140688 | 0.89 | PDE3B (1.00) | PDE3BPDE3AALDH1A1HPGDNPSR1 | |
| SCHEMBL18796725 | 0.89 | PDE3B (0.80) | PDE3BPDE3AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL18796764 | 0.89 | PDE3B (0.80) | PDE3BPDE3AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL17480161 | 0.89 | PDE3B (0.80) | PDE3BPDE3AALDH1A1HPGDNPSR1 | |
| SCHEMBL18796755 | 0.88 | PDE3B (0.81) | PDE3BPDE3AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL18796705 | 0.88 | PDE3B (0.74) | PDE3BPDE3AALDH1A1MEN1KMT2A | |
| SCHEMBL18796759 | 0.87 | PDE3B (0.77) | PDE3BPDE3AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL18796677 | 0.87 | PDE3B (0.65) | PDE3BPDE3AALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017072796-A1 | 2-PYRIDONE BASED COMPOUNDS USEFUL AS POTENTIAL PHOSPHODIESTERASE3A (PDE3A)INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-05-04 | — | — | WO | claimed |
| WO-2017072796-A1 | 2-PYRIDONE BASED COMPOUNDS USEFUL AS POTENTIAL PHOSPHODIESTERASE3A (PDE3A)INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-05-04 | — | — | WO | disclosed |
| WO-2017072796-A1 | 2-PYRIDONE BASED COMPOUNDS USEFUL AS POTENTIAL PHOSPHODIESTERASE3A (PDE3A)INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-05-04 | — | — | WO | disclosed |