⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11815232 | 0.87 | — | — | |
| SCHEMBL11825332 | 0.84 | CYP2C19 (0.32) | — | |
| SCHEMBL2002432 | 0.84 | CYP2C19 (0.32) | — | |
| SCHEMBL22323 | 0.71 | — | — | |
| SCHEMBL22324 | 0.71 | — | — | |
| SCHEMBL1766564 | 0.69 | — | — | |
| Hydrochloric Acid SCHEMBL11173116 | 0.69 | — | — | |
| SCHEMBL19086911 | 0.69 | — | — | |
| SCHEMBL1766560 | 0.69 | — | — | |
| SCHEMBL2015440 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0461483-B1 | Method for the production of benzyl ketones | BAYER AG (DE) | 1995-11-02 | — | — | EP | claimed |
| US-5146001-A | PREPARATION OF BENZYL KETONES AND AN OXIRANE | BAYER AKTIENGESELLSCHAFT (DE) | 1992-09-08 | — | — | US | claimed |
| CN-116874358-B | Synthesis method of prothioconazole intermediate 2-chlorobenzyl- (1-chlorocyclopropyl) ketone | 辽宁众辉生物科技有限公司 | 2024-08-02 | — | — | CN | disclosed |
| CN-115124440-B | Preparation method of prothioconazole intermediate | 江苏七洲绿色科技研究院有限公司 | 2024-05-31 | — | — | CN | disclosed |
| CN-117624080-A | Synthesis method of prothioconazole intermediate | 绍兴上虞新银邦生化有限公司 | 2024-03-01 | — | — | CN | disclosed |
| CN-116874358-A | Clean synthesis method of prothioconazole intermediate 2-chlorobenzyl- (1-chlorocyclopropyl) ketone | 辽宁众辉生物科技有限公司 | 2023-10-13 | — | — | CN | disclosed |
| CN-115124440-A | Preparation method of prothioconazole intermediate | 江苏七洲绿色科技研究院有限公司 | 2022-09-30 | — | — | CN | disclosed |
| CN-114432900-A | Preparation method of anti-pollution composite reverse osmosis membrane and anti-pollution composite reverse osmosis membrane prepared by same | 沃顿科技股份有限公司 | 2022-05-06 | — | — | CN | disclosed |
| US-11292775-B2 | Efficient process for the synthesis of 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione(prothioconazole) and its intermediates | GSP CROP SCIENCE PVT. LTD. (IN) | 2022-04-05 | — | — | US | disclosed |
| US-20200369627-A1 | IMPROVED AND EFFICIENT PROCESS FOR THE SYNTHESIS OF 2-[2-(1-CHLOROCYCLOPROPYL)-3-(2-CHLOROPHENYL)-2-HYDROXYPROPYL]-2,4-DIHYDRO-3H-1,2,4-TRIAZOLE-3-THIONE(PROTHIOCONAZOLE) AND ITS INTERMEDIATES | GSP CROP SCIENCE PVT. LTD. (IN) | 2020-11-26 | — | — | US | disclosed |
| CN-111527071-A | Improved and efficient process for the synthesis of 2- [2- (1-chlorocyclopropyl) -3- (2-chlorophenyl) -2-hydroxypropyl ] -2, 4-dihydro-3H-1, 2, 4-triazole-3-thione (prothioconazole) and intermediates thereof | GSP作物科学有限公司 | 2020-08-11 | — | — | CN | disclosed |
| EP-1902026-A2 | TETRAHYDROCARBAZOLE DERIVATIVES USEFUL AS ANDROGEN RECEPTOR MODULATORS (SARM) | ELI LILLY AND COMPANY (US) | 2008-03-26 | — | — | EP | disclosed |
| EP-1898927-A2 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | Merck & Co., Inc. (US) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007002181-A2 | TETRAHYDROCARBAZOLE DERIVATIVES USEFUL AS ANDROGEN RECEPTOR MODULATORS (SARM) | ELI LILLY AND COMPANY (US) | 2007-01-04 | — | — | WO | disclosed |
| WO-2007002481-A2 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | MERCK & CO., INC. (US) | 2007-01-04 | — | — | WO | disclosed |
| US-5194636-A | Preparation of benzyl ketones and an oxirane | BAYER AKTIENGESELLSCHAFT (DE) | 1993-03-16 | — | — | US | disclosed |
| US-5146001-A | PREPARATION OF BENZYL KETONES AND AN OXIRANE | BAYER AKTIENGESELLSCHAFT (DE) | 1992-09-08 | — | — | US | disclosed |
| US-4410529-A | HYPOTENSIVE AGNENTS, ANTICOAGULANTS | BASF AKTIENGESELLSCHAFT (DE) | 1983-10-18 | — | — | US | disclosed |
| US-4271163-A | HYPOTENSIVE AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 1981-06-02 | — | — | US | disclosed |
| US-4166735-A | Cycloalkanecarboxanilide derivative herbicides | SHELL OIL COMPANY (US) | 1979-09-04 | — | — | US | disclosed |