Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH1 | Q92800 | 3/20 | 0.42 |
| ▸ | EZH2 | Q15910 | 11/20 | 0.41 |
| ▸ | PDE1A | P54750 | 4/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.40 |
| ▸ | PDE9A | O76083 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800382 | 0.93 | EZH1 (0.44) | EZH1EZH2PDE1CPDE9A | |
| SCHEMBL18800379 | 0.91 | EZH1 (0.42) | EZH1EZH2PDE1CPDE9A | |
| SCHEMBL18800384 | 0.87 | PDE9A (0.45) | EZH1EZH2PDE1CPDE9A | |
| SCHEMBL18800360 | 0.87 | EZH2 (0.43) | EZH1EZH2PDE1APDE1BPDE1C | |
| SCHEMBL12684442 | 0.86 | EZH1 (0.52) | EZH1EZH2 | |
| SCHEMBL18800350 | 0.84 | EZH2 (0.54) | EZH1EZH2PDE9A | |
| SCHEMBL18800352 | 0.84 | EZH1 (0.43) | EZH1EZH2PDE1CPDE9A | |
| SCHEMBL18800424 | 0.80 | EZH1 (0.41) | EZH1EZH2PDE1CPDE9A | |
| SCHEMBL12684434 | 0.79 | EZH2 (0.55) | EZH1EZH2 | |
| SCHEMBL25543956 | 0.79 | EZH2 (0.51) | EZH1EZH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3323820-B1 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | EPIZYME INC (US) | 2023-05-10 | — | — | EP | disclosed |
| US-9637472-B2 | Substituted 6,5-fused bicyclic heteroaryl compounds | Epizyme, Inc. (US) | 2017-05-02 | — | — | US | disclosed |